Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.
Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.
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DOI：
10.1126/sciadv.abg7700
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发表时间：
2021-12-17
期刊：
影响因子：
13.6
通讯作者：
Rushworth MFS
中科院分区：
文献类型：
--
作者：
Folloni D;Fouragnan E;Wittmann MK;Roumazeilles L;Tankelevitch L;Verhagen L;Attali D;Aubry JF;Sallet J;Rushworth MFS
灵长类动物47/12 o区的非侵入性超声刺激破坏了与信用分配相关的行为和神经活动。信用分配是特定奖励实例与导致它们的特定事件（例如特定选择）的关联。如果没有信用分配，选择值反映的是做出选择时对环境的大致估计，即全球回报状态，而不是选择导致的确切结果。经颅超声刺激（TUS）和功能性磁共振成像在猕猴中的组合表现出前额叶47/12 o区的信用分配相关活动，当该信号被TUS破坏时，整个大脑的选择值表征受损。结果，行为不再受选择价值的指导，决策能力也更差。相比之下，在前额叶中断后，邻近的前额叶中与全球奖励状态相关的活动保持不变，并决定了决策。
Noninvasive ultrasound stimulation of primate area 47/12o disrupts credit assignment–related behavior and neural activity. Credit assignment is the association of specific instances of reward to the specific events, such as a particular choice, that caused them. Without credit assignment, choice values reflect an approximate estimate of how good the environment was when the choice was made—the global reward state—rather than exactly which outcome the choice caused. Combined transcranial ultrasound stimulation (TUS) and functional magnetic resonance imaging in macaques demonstrate credit assignment–related activity in prefrontal area 47/12o, and when this signal was disrupted with TUS, choice value representations across the brain were impaired. As a consequence, behavior was no longer guided by choice value, and decision-making was poorer. By contrast, global reward state–related activity in the adjacent anterior insula remained intact and determined decision-making after prefrontal disruption.
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