Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
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DOI：
10.2337/dc09-1996
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发表时间：
2010-05
期刊：
影响因子：
16.2
通讯作者：
Atherosclerosis Risk in Communities Investigators
中科院分区：
文献类型：
--
作者：
Luft VC;Schmidt MI;Pankow JS;Hoogeveen RC;Couper D;Heiss G;Duncan BB;Atherosclerosis Risk in Communities Investigators
二肽基肽酶IV （DPP-IV）不仅在β细胞功能中起重要作用，而且具有促炎作用。我们的目的是研究它是否可以作为低级别慢性炎症和糖尿病之间的联系。采用病例队列设计，我们在社区动脉粥样硬化风险研究中随访了546名患有糖尿病的中年人和538名未超过9年的中年人。在加权分析中，DPP-IV水平与人体测量、炎症或代谢变量之间的相关性很小（Spearman相关性<0.11）。糖尿病患者的平均DPP-IV值与未患糖尿病的患者相似（P = 0.18）。在校正了年龄、性别、种族、研究中心和多个附加糖尿病危险因素的Cox比例风险模型中，DPP-IV最高四分位数的个体并没有更高的糖尿病风险（风险比0.88 [95% CI 0.62-1.24]）。空腹DPP-IV水平似乎不能预测糖尿病的发生。
Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over ∼9 years within the Atherosclerosis Risk in Communities study. In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62–1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors. Fasting DPP-IV levels do not appear to predict incident diabetes.
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DOI：
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发表时间：
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