ZikaPLAN: Zika Preparedness Latin American Network.
ZikaPLAN: Zika Preparedness Latin American Network.
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DOI：
10.1080/16549716.2017.1398485
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发表时间：
2017
影响因子：
2.6
通讯作者：
Massad E
中科院分区：
文献类型：
--
作者：
Wilder-Smith A;Preet R;Renhorn KE;Ximenes RA;Rodrigues LC;Solomon T;Neyts J;Lambrechts L;Willison H;Peeling R;Falconar AK;Precioso AR;Logan J;Lang T;Endtz HP;Erasmus MC;Massad E
目前寨卡病毒（ZIKV）在拉丁美洲、加勒比和太平洋岛屿的爆发强调了在整个地区建立一个协调的研究网络的必要性，该网络可以迅速应对目前寨卡病毒的知识缺口，并加强寨卡病毒以外的研究准备。欧盟在其“地平线2020研究与创新计划”下授予了三个研究财团以应对这一需求。Zika Preparedness Latin American Network（Zika Preparedness Latin American Network）。ZikaMonkey结合了拉丁美洲，北美，非洲，亚洲和欧洲各个中心的25个合作伙伴的优势。我们将开展临床研究，以评估风险，并进一步确定先天性寨卡病毒综合征的全谱和风险因素（包括生命最初3年的神经发育里程碑），描述由于年龄较大的儿童和成人的直接神经侵袭和免疫介导的反应而与ZIKV相关的神经系统并发症，并加强对出生缺陷和格林-巴利综合征的监测。基于实验室的研究，以解开神经嗜性和调查性传播的作用，严重疾病的决定因素，和病毒的健身将支持临床研究。社会信息和与受影响社区的接触，以及针对伊蚊的可穿戴驱蚊技术的发展将加强影响。疾病研究、数据驱动的病媒控制、疫苗建模以及ZIKV地理传播的风险评估将为循证政策奠定基础。在解决ZIKV研究空白的同时，我们将参与实验室和临床研究的能力建设，与现有和新的网络合作分享知识，并与国际组织合作解决监管和其他瓶颈问题，优化研究优先事项。通过这种方式，我们可以利用ZIKV应对措施，在该地区建立长期的新发传染病应对能力，以应对未来的挑战。
The ongoing Zika virus (ZIKV) outbreak in Latin America, the Caribbean, and the Pacific Islands has underlined the need for a coordinated research network across the whole region that can respond rapidly to address the current knowledge gaps in Zika and enhance research preparedness beyond Zika. The European Union under its Horizon 2020 Research and Innovation Programme awarded three research consortia to respond to this need. Here we present the ZikaPLAN (Zika Preparedness Latin American Network) consortium. ZikaPLAN combines the strengths of 25 partners in Latin America, North America, Africa, Asia, and various centers in Europe. We will conduct clinical studies to estimate the risk and further define the full spectrum and risk factors of congenital Zika virus syndrome (including neurodevelopmental milestones in the first 3 years of life), delineate neurological complications associated with ZIKV due to direct neuroinvasion and immune-mediated responses in older children and adults, and strengthen surveillance for birth defects and Guillain–Barré Syndrome. Laboratory-based research to unravel neurotropism and investigate the role of sexual transmission, determinants of severe disease, and viral fitness will underpin the clinical studies. Social messaging and engagement with affected communities, as well as development of wearable repellent technologies against Aedes mosquitoes will enhance the impact. Burden of disease studies, data-driven vector control, and vaccine modeling as well as risk assessments on geographic spread of ZIKV will form the foundation for evidence-informed policies. While addressing the research gaps around ZIKV, we will engage in capacity building in laboratory and clinical research, collaborate with existing and new networks to share knowledge, and work with international organizations to tackle regulatory and other bottlenecks and refine research priorities. In this way, we can leverage the ZIKV response toward building a long-term emerging infectious diseases response capacity in the region to address future challenges.
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影响因子：
11.1
作者：
Rocklöv J;Quam MB;Sudre B;German M;Kraemer MUG;Brady O;Bogoch II;Liu-Helmersson J;Wilder-Smith A;Semenza JC;Ong M;Aaslav KK;Khan K
通讯作者：
Khan K
影响因子：
11.1
作者：
Liu-Helmersson J;Quam M;Wilder-Smith A;Stenlund H;Ebi K;Massad E;Rocklöv J
通讯作者：
Rocklöv J
影响因子：
4.2
作者：
Massad, E.;Nascimento Burattini, M.;Wilder-Smith, A.
通讯作者：
Wilder-Smith, A.
影响因子：
8.8
作者：
Azevedo, Raimunda S. S.;Araujo, Marialva T.;Vasconcelos, Pedro F. C.
通讯作者：
Vasconcelos, Pedro F. C.
影响因子：
12
作者：
de Magalhaes-Barbosa, Maria Clara;Prata-Barbosa, Arnaldo;Lima-Setta, Fernanda
通讯作者：
Lima-Setta, Fernanda