Cervical cancer incidence after up to 20 years of observation among women with HIV.
Cervical cancer incidence after up to 20 years of observation among women with HIV.
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DOI：
10.1002/ijc.30866
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发表时间：
2017-10-15
影响因子：
6.4
通讯作者：
Seaberg EC
中科院分区：
文献类型：
--
作者：
Massad LS;Hessol NA;Darragh TM;Minkoff H;Colie C;Wright RL;Cohen M;Seaberg EC
为了估计人类免疫缺陷病毒（HIV）感染妇女21年随访期间浸润性宫颈癌（ICC）的发病率，并将其与未感染HIV的妇女进行比较，我们回顾了一项为期20年的多中心美国队列研究中的ICC诊断，该研究对每6个月进行一次巴氏试验的HIV感染和未感染妇女进行了研究。计算发病率，并与HIV阴性妇女进行比较。发病率比标准化的年龄，性别，种族，和特定人群的年率进行了计算。经过12.3年的中位随访，在艾滋病毒血清反应阳性的妇女中确认了4例ICC，在过去10年的观察中只有1例，在血清反应阴性的妇女中没有一例。ICC的发病率没有显着差异，艾滋病毒状态（艾滋病毒血清阴性：0/100，000人-年与艾滋病毒血清阳性：19.5/100，000人-年; p=0.53）。HIV感染WIHS参与者的标准化发病率为3.31（95% CI：0.90，8.47; p=0.07）。虽然在没有艾滋病毒的妇女中稍微更常见，但对于那些在预防计划中感染艾滋病毒的妇女来说，ICC不会随着妇女年龄的增长而成为主要威胁。
In order to estimate the incidence of invasive cervical cancer (ICC) across up to 21 years of follow-up among women with human immunodeficiency virus (HIV) and to compare it to that among HIV-uninfected women, we reviewed ICC diagnoses from a 20-year multi-site U.S. cohort study of HIV infected and uninfected women who had Pap testing every six months. Incidence rates were calculated and compared to those in HIV-negative women. Incidence ratios standardized to age-, sex-, race-, and calendar-year specific population rates were calculated. After a median follow-up of 12.3 years, four ICCs were confirmed in HIV seropositive women, only one in the last 10 years of observation, and none in seronegative women. The ICC incidence rate did not differ significantly by HIV status (HIV seronegative: 0/100,000 person-years vs. HIV seropositive: 19.5/100,000 person-years; p=0.53). The standardized incidence ratio for the HIV-infected WIHS participants was 3.31 (95% CI: 0.90, 8.47; p=0.07). Although marginally more common in women without HIV, for those with HIV in a prevention program, ICC does not emerge as a major threat as women age.
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影响因子：
--
作者：
Simard, Edgar P.;Pfeiffer, Ruth M.;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
3
作者：
Thorsteinsson, K.;Ladelund, S.;Lebech, A-M
通讯作者：
Lebech, A-M
影响因子：
5.4
作者：
Barkan, SE;Melnick, SL;Feldman, J
通讯作者：
Feldman, J
影响因子：
10.3
作者：
Chaturvedi, Anil K.;Madeleine, Margaret M.;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
9.8
作者：
Massad, L. Stewart;Xie, Xianhong;D'Souza, Gypsyamber;Darragh, Teresa M.;Minkoff, Howard;Wright, Rodney;Colie, Christine;Sanchez-Keeland, Lorraine;Strickler, Howard D.
通讯作者：
Strickler, Howard D.