Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants
Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants
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人类新皮质发育是了解极早产儿神经发育障碍机制的基础
DOI：
10.1111/jog.14468
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发表时间：
2020
影响因子：
1.6
通讯作者：
Deguchi Kimiko
中科院分区：
文献类型：
--
作者：
Kubo Ken‐ichiro;Deguchi Kimiko
近年来，随着围产期和新生儿医学的发展，世界各地的极早产儿（妊娠28周前出生）的存活率显著提高，日本是极早产儿存活率最高的国家之一。然而，许多幸存者在以后的生活中发展神经发育障碍，包括认知功能障碍和神经发育障碍，这仍然是一个主要问题。为了了解神经发育障碍的病理生理机制观察到的幸存者的极早产，我们回顾了最近报道的结果有关的发展人类neocorticity.MethodsFirst，我们总结了目前的知识有关的发展的新皮层，包括最近报道的人类和/或灵长类动物特定的发展事件。接下来，我们讨论了潜在的因果机制的发展，神经发育障碍的极早产infants.ResultsAround出生的极早产儿，神经发生和随后的神经元迁移正在进行中的大脑新皮层。扩张和成熟的基板，这被认为是反映轴突布线在新皮层，也是突出的，在这个时候，conclusionBrain injury发生在出生的极早产儿被推定为影响动态发展的事件，在新皮层，如神经发生，神经元迁移和成熟的基板，这可能是极早产儿随后经常发展的神经发育障碍的基础。在考虑孕产妇和新生儿护理以进一步改善极早产儿的长期结局时，应牢记这些可能性。
AimRecent advances in perinatal and neonatal medicine have resulted in marked improvements in the survival rates of extremely preterm infants (born before 28 gestational weeks) around the world, and Japan is among the countries with the highest reported survival rates of extremely preterm infants. However, it remains a major concern that many survivors develop neurodevelopmental disabilities, including cognitive dysfunctions and neurodevelopmental disorders later in life. In order to understand the pathophysiological mechanisms underlying the neurodevelopmental disabilities observed in the survivors of extremely preterm births, we reviewed recently reported findings about the development of the human neocortex.MethodsFirst, we have summarized the current knowledge about the development of the neocortex, including recently reported human‐ and/or primate‐specific developmental events. Next, we discussed the possible causal mechanisms underlying the development of neurodevelopmental disabilities in extremely preterm infants.ResultsAround the birth of extremely preterm infants, neurogenesis and succeeding neuronal migrations are ongoing in the neocortex of human brain. Expansion and maturation of the subplate, which is thought to reflect the axonal wiring in the neocortex, is also prominent at this time.ConclusionBrain injuries that occur around the birth of extremely preterm infants are presumed to affect the dynamic developmental events in the neocortex, such as neurogenesis, neuronal migrations and maturation of the subplate, which could underlie the neurodevelopmental disabilities that often develop subsequently in extremely preterm infants. These possibilities should be borne in mind while considering maternal and neonatal care to further improve the long‐term outcomes of extremely preterm infants.
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影响因子：
2.4
作者：
Botellero VL;Skranes J;Bjuland KJ;Håberg AK;Lydersen S;Brubakk AM;Indredavik MS;Martinussen M
通讯作者：
Martinussen M
影响因子：
39.2
作者：
Scholes, D;Hooton, TM;Stamm, WE
通讯作者：
Stamm, WE
DOI：
10.1523/jneurosci.23-31-09996.2003
发表时间：
2003-11
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
H. Tabata;K. Nakajima
通讯作者：
H. Tabata;K. Nakajima
影响因子：
11.2
作者：
Back SA;Miller SP
通讯作者：
Miller SP
影响因子：
3.8
作者：
Deguchi, K;Oguchi, K;Takashima, S
通讯作者：
Takashima, S