Muscle-Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies.
Muscle-Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies.
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DOI：
10.3390/biomedicines5040062
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发表时间：
2017-10-24
期刊：
影响因子：
4.7
通讯作者：
Lara-Castillo N
中科院分区：
文献类型：
--
作者：
Maurel DB;Jähn K;Lara-Castillo N
骨质疏松症和肌肉减少症是与年龄相关的肌肉骨骼疾病，通常平行发展。骨质疏松症的特征是骨量减少和骨折风险增加。肌肉减少症描述了肌肉萎缩，由于福尔斯而受伤的风险增加。这两种疾病的医疗每年花费数十亿美元的医疗保健费用。随着对公共卫生和经济的影响，并考虑到人口预期寿命的增加，寻求更有效的治疗方案。这两种组织与肌肉作用于骨之间的生物力学相互作用是明确的。最近，这两种组织也被确定为相互影响功能的分泌内分泌器官。在这方面，每年都有令人兴奋的新发现，发现了新的信号分子，并描述了潜在的争议。虽然这篇综述并不要求完整性，但它将总结肌肉和骨骼之间生物力学和生物化学联系的现有知识。该综述将突出两种组织影响另一种组织的已知分泌分子，并对可能从这些发现中出现的新疗法进行展望。
Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often develop in parallel. Osteoporosis is characterized by a reduced bone mass and an increased fracture risk. Sarcopenia describes muscle wasting with an increasing risk of injuries due to falls. The medical treatment of both diseases costs billions in health care per year. With the impact on public health and economy, and considering the increasing life expectancy of populations, more efficient treatment regimens are sought. The biomechanical interaction between both tissues with muscle acting on bone is well established. Recently, both tissues were also determined as secretory endocrine organs affecting the function of one another. New exciting discoveries on this front are made each year, with novel signaling molecules being discovered and potential controversies being described. While this review does not claim completeness, it will summarize the current knowledge on both the biomechanical and the biochemical link between muscle and bone. The review will highlight the known secreted molecules by both tissues affecting the other and finish with an outlook on novel therapeutics that could emerge from these discoveries.
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