Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury.
Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury.
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白藜芦醇增强脊髓中 IL-4 受体介导的抗炎作用并减轻坐骨神经损伤后的神经性疼痛
DOI：
10.1177/1744806918767549
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发表时间：
2018-01
期刊：
影响因子：
3.3
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Xu M;Cheng Z;Ding Z;Wang Y;Guo Q;Huang C
白藜芦醇已被证明通过对周围神经系统的抗炎作用来缓解神经病理性疼痛。然而，目前尚不清楚白藜芦醇，特别是在全身给药时，是否有效地缓解了周围神经病引起的中枢神经系统促炎和抗炎反应之间的失衡。为了验证这一点，我们使用了一种由坐骨神经慢性压迫损伤引起的大鼠神经病理性疼痛模型。慢性缩窄性损伤后给予白藜芦醇(200 mg/kg)或赋形剂(二甲基亚砜)，每日1次，连续14d。我们发现，白藜芦醇可以减轻慢性缩窄性损伤大鼠的机械痛觉过敏和热痛觉过敏。白藜芦醇治疗14d后，慢性压迫性损伤大鼠脊髓背侧IL-1RA、IL-1R2等抗炎细胞因子受体表达增加，脊髓背侧神经元IL-4Rα表达增加。在神经细胞系中敲除IL-4Rα可逆转白藜芦醇诱导的IL-1RA和IL-1R2上调。这些结果表明，白藜芦醇增强了IL-4受体介导的脊髓抗炎反应，从而可能有助于减轻周围神经损伤后的中枢敏感化。
Resveratrol has been showed to relieve neuropathic pain through its anti-inflammatory effects on the peripheral nerve system. However, it is not clear whether resveratrol, especially when administered systemically, is effective in alleviating the peripheral neuropathy-induced imbalance between pro- and anti-inflammatory responses in the central nervous system. To test this, we used a rat neuropathic pain model resulting from chronic constriction injury of the sciatic nerve. Resveratrol (200 mg/kg) or vehicle (dimethylsulfoxide) were administered intraperitoneally once daily for 14 consecutive days after chronic constriction injury. We found that resveratrol attenuated mechanical allodynia and thermal hyperalgesia in rats with chronic constriction injury. After 14 days of resveratrol treatment, expression of several anti-inflammatory cytokine receptors, including IL-1RA and IL-1R2, was increased in the dorsal spinal cord of rats with chronic constriction injury, and IL-4Rα was increased in dorsal spinal cord neurons. Knockdown of IL-4Rα in a neuronal cell line reversed the resveratrol-induced upregulation of IL-1RA and IL-1R2. These results indicate that resveratrol enhances IL-4 receptor-mediated anti-inflammatory responses in the spinal cord and thus might contribute to the alleviation of central sensitization following peripheral nerve injury.
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影响因子：
3.3
作者：
Liu T;Jiang CY;Fujita T;Luo SW;Kumamoto E
通讯作者：
Kumamoto E
DOI：
10.1084/jem.191.2.313
发表时间：
2000-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Horai R;Saijo S;Tanioka H;Nakae S;Sudo K;Okahara A;Ikuse T;Asano M;Iwakura Y
通讯作者：
Iwakura Y
Interleukin-1家族：回到未来。
影响因子：
32.4
作者：
Garlanda C;Dinarello CA;Mantovani A
通讯作者：
Mantovani A
影响因子：
15.1
作者：
Peters, Vanessa A.;Joesting, Jennifer J.;Freund, Gregory G.
通讯作者：
Freund, Gregory G.
影响因子：
7.4
作者：
BENNETT, GJ;XIE, YK
通讯作者：
XIE, YK