Cigarette smoking, alcohol intake, and risk of glioma in the NIH-AARP Diet and Health Study.
Cigarette smoking, alcohol intake, and risk of glioma in the NIH-AARP Diet and Health Study.
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DOI：
10.1038/bjc.2013.611
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发表时间：
2014-01-07
影响因子：
8.8
通讯作者：
Kitahara, C. M.
中科院分区：
文献类型：
--
作者：
Braganza, M. Z.;Rajaraman, P.;Park, Y.;Inskip, P. D.;Freedman, N. D.;Hollenbeck, A. R.;de Gonzalez, A. Berrington;Kitahara, C. M.
虽然吸烟和饮酒会增加患几种癌症的风险，而且香烟烟雾和酒精的某些成分可以穿透血脑屏障，但目前尚不清楚这些暴露是否会影响神经胶质瘤的风险。我们在美国国立卫生研究院-美国退休人员协会饮食与健康研究中检查了吸烟、饮酒和神经胶质瘤风险之间的关系，这是一项前瞻性研究，共有477095名美国男性和女性参加，基线年龄为50-71岁。使用以年龄为时间指标的模型计算风险比（HR）和95%置信区间（CI），并根据性别、人种/种族、教育和婚姻状况进行调整。在平均10.5人年的随访中，492名男性和212名女性被诊断为首次原发性胶质瘤。在男性中，与从不吸烟相比，目前较重的吸烟与神经胶质瘤风险降低有关，但这仅基于9例病例。在女性中，吸烟行为与神经胶质瘤风险之间没有观察到关联。更多的饮酒量与神经胶质瘤风险降低相关，尤其是在男性中（每天>2杯vs每周<1杯：HR=0.67，95%CI =0.51-0.90）。吸烟和饮酒似乎不会增加患神经胶质瘤的风险。
Although cigarette smoking and alcohol drinking increase the risk of several cancers and certain components of cigarette smoke and alcohol can penetrate the blood–brain barrier, it remains unclear whether these exposures influence the risk of glioma. We examined the associations between cigarette smoking, alcohol intake, and risk of glioma in the National Institutes of Health-AARP Diet and Health Study, a prospective study of 477 095 US men and women ages 50–71 years at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using models with age as the time metric and adjusted for sex, race/ethnicity, education, and marital status. During a median 10.5 person-years of follow-up, 492 men and 212 women were diagnosed with first primary glioma. Among men, current, heavier smoking was associated with a reduced risk of glioma compared with never smoking, but this was based on only nine cases. No associations were observed between smoking behaviours and glioma risk in women. Greater alcohol consumption was associated with a decreased risk of glioma, particularly among men (>2 drinks per day vs <1 drink per week: HR=0.67, 95% CI=0.51–0.90). Smoking and alcohol drinking do not appear to increase the risk of glioma.
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影响因子：
5.1
作者：
Festa, Michela;Capasso, Anna;Piacente, Sonia
通讯作者：
Piacente, Sonia
影响因子：
15.9
作者：
Dolecek, Therese A.;Propp, Jennifer M.;Kruchko, Carol
通讯作者：
Kruchko, Carol
影响因子：
6.3
作者：
Hurley, SF;McNeil, JJ;Giles, GG
通讯作者：
Giles, GG
影响因子：
2.3
作者：
Kitahara, Cari M.;Linet, Martha S.;Freeman, Laura E. Beane;Check, David P.;Church, Timothy R.;Park, Yikyung;Purdue, Mark P.;Schairer, Catherine;de Gonzalez, Amy Berrington
通讯作者：
de Gonzalez, Amy Berrington
影响因子：
6.4
作者：
MCLAUGHLIN, JK;LINDBLAD, P;ADAMI, HO
通讯作者：
ADAMI, HO