Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline.
Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline.
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DOI：
10.3389/fnagi.2021.646017
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Chen Q;Lu J;Zhang X;Sun Y;Chen W;Li X;Zhang W;Qing Z;Zhang B
目的：探讨主观认知衰退（SCD）个体的动态功能连接（DFC）和静态图论参数，以及DFC和拓扑特性与认知表现的关系。方法：选取33名对照组和32名SCD患者，进行神经心理评估和静息状态功能磁共振成像扫描。通过群独立分量分析，选取33个分量构建7个功能网络。基于滑动窗口方法和k-means聚类，识别出不同的DFC状态。我们计算了每个状态下分数窗的时间特性，每个状态下的平均停留时间，以及每对DFC状态之间的转换次数。采用图论分析方法对全局静态参数和局部静态参数进行了评估。评估了DFC和拓扑指标的差异，以及改变的神经影像学测量与认知表现的关联。结果：整个队列表现出4种不同的连接状态。与对照组相比，SCD组表现出更多的窗口分数和状态4的平均停留时间，其特征是网络内部和网络之间的低连通性。SCD组在状态2中也显示出间隔窗口的减少和平均停留时间的减少，主要是听觉、视觉和躯体运动网络内部和之间的超连接。与对照组相比，SCD组在状态1到状态2、状态2到状态3、状态2到状态4之间的转换次数显著减少。在全局或局部拓扑指标上没有观察到显著差异。DFC属性的改变与认知表现有显著的相关性。结论：我们的研究结果表明，DFC网络重构在SCD阶段可能是SCD受试者早期认知能力下降的基础，并可作为早期阿尔茨海默病个体临床前检测的敏感神经影像学生物标志物。
Purpose: To investigate the dynamic functional connectivity (DFC) and static parameters of graph theory in individuals with subjective cognitive decline (SCD) and the associations of DFC and topological properties with cognitive performance. Methods: Thirty-three control subjects and 32 SCD individuals were enrolled in this study, and neuropsychological evaluations and resting-state functional magnetic resonance imaging scanning were performed. Thirty-three components were selected by group independent component analysis to construct 7 functional networks. Based on the sliding window approach and k-means clustering, distinct DFC states were identified. We calculated the temporal properties of fractional windows in each state, the mean dwell time in each state, and the number of transitions between each pair of DFC states. The global and local static parameters were assessed by graph theory analysis. The differences in DFC and topological metrics, and the associations of the altered neuroimaging measures with cognitive performance were assessed. Results: The whole cohort demonstrated 4 distinct connectivity states. Compared to the control group, the SCD group showed increased fractional windows and an increased mean dwell time in state 4, characterized by hypoconnectivity both within and between networks. The SCD group also showed decreased fractional windows and a decreased mean dwell time in state 2, dominated by hyperconnectivity within and between the auditory, visual and somatomotor networks. The number of transitions between state 1 and state 2, between state 2 and state 3, and between state 2 and state 4 was significantly reduced in the SCD group compared to the control group. No significant differences in global or local topological metrics were observed. The altered DFC properties showed significant correlations with cognitive performance. Conclusion: Our findings indicated DFC network reconfiguration in the SCD stage, which may underlie the early cognitive decline in SCD subjects and serve as sensitive neuroimaging biomarkers for the preclinical detection of individuals with incipient Alzheimer's disease.
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DOI：
10.1016/j.nicl.2017.08.006
发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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