Female Sprague-Dawley rats display greater appetitive and consummatory responses to alcohol.
Female Sprague-Dawley rats display greater appetitive and consummatory responses to alcohol.
复制标题
DOI：
10.1016/j.bbr.2017.03.037
复制
发表时间：
2017-06-01
影响因子：
2.7
通讯作者：
Kosten TA
中科院分区：
文献类型：
--
作者：
Nieto SJ;Kosten TA
饮酒模式方面的性别差距缩小令人关切，因为妇女更容易受到饮酒对健康的不利影响。酒精寻求和消费的动物模型是有用的描绘性别差异，以测试有效的性别特异性药物治疗。我们调查了对酒精的食欲和消费反应的潜在性别差异。食欲行为包括头部进入铲斗进入区域和主动杠杆按压的次数。消费行为包括交付和消费的饮料数量。将雄性和雌性Sprague-Dawley大鼠置于过夜酒精（10%）饮用时间表中，并训练其杠杆按压酒精（10%溶液）。单独组的雄性和雌性动物可获得水过夜，并接受培训以使用杠杆按压蔗糖（3%溶液）。试验是在一个渐进的配筋率方案下进行的。酒精反应的女性表现出更高的酒精摄入量过夜，并表现出更大的食欲和消费的反应相比，男性。在蔗糖组中也观察到类似的性别差异。效应量表明酒精组与蔗糖组在完善措施方面存在更大的性别差异。相反，在蔗糖与酒精组中观察到食欲行为的性别差异更大。总的来说，与完成行为相比，食欲行为的性别差异幅度更大。酒精和天然甜味剂蔗糖的食欲和消费行为的定量性别差异的结果表明，该程序是有用的，以评估疗效的性别特异性治疗，旨在减少食欲和消费反应的酒精。
The narrowing of the gender gap in alcohol drinking patterns is a concern because women are more susceptible to adverse health consequences of alcohol use. Animal models of alcohol-seeking and –consuming are useful to delineate sex differences to test for effective sex-specific pharmacological treatments. We investigated potential sex differences in appetitive and consummatory responses to alcohol. Appetitive behaviors included numbers of head entries into the dipper access area and active lever presses. Consummatory behaviors included number of reinforcers delivered and consumed. Male and female Sprague-Dawley rats were placed on an overnight alcohol (10%) drinking schedule and trained to lever press for alcohol (10% solution). Separate groups of male and female animals had access to water overnight and were trained to lever press for sucrose (3% solution). Tests were conducted under a progressive ratio schedule of reinforcement. Alcohol-responding females demonstrated higher alcohol intake overnight and showed greater appetitive and consummatory responses compared to males. Similar sex differences were seen in the sucrose group. Effect sizes indicated greater sex differences in consummatory measures in the alcohol vs. sucrose groups. Conversely, greater sex differences in appetitive behaviors were observed in the sucrose vs. alcohol groups. Overall, the magnitude of the sex differences was stronger for appetitive behaviors compared to consummatory behaviors. Findings of quantitative sex differences in appetitive and consummatory behaviors for alcohol and for the natural reinforcer, sucrose, suggest this procedure is useful to assess efficacy of sex-specific treatments aimed at reducing appetitive and consummatory responses to alcohol.
登录
查看更多内容
影响因子：
4.2
作者：
Becker, Jill B.;McClellan, Michele L.;Reed, Beth Glover
通讯作者：
Reed, Beth Glover
影响因子：
2.9
作者：
Barson, Jessica R.;Morganstern, Irene;Leibowitz, Sarah F.
通讯作者：
Leibowitz, Sarah F.
影响因子：
3.4
作者：
Lynch, Wendy J.
通讯作者：
Lynch, Wendy J.
影响因子：
5.5
作者：
Bouchery, Ellen E.;Harwood, Henrick J.;Brewer, Robert D.
通讯作者：
Brewer, Robert D.
影响因子：
39.2
作者：
KLATSKY, AL;ARMSTRONG, MA;FRIEDMAN, GD
通讯作者：
FRIEDMAN, GD