Dynamical changes in neurological diseases and anesthesia.-猫眼课题宝

DOI：

10.1016/j.conb.2012.02.009

发表时间：

2012-08

期刊：

Current opinion in neurobiology

影响因子：

5.7

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

McCarthy MM;Ching S;Whittington MA;Kopell N

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965179/?report=classic

神经元网络的动力学至少可以通过两种方式改变：通过连接性的变化，即网络的物理结构，或者组成网络的元件内部和之间的内在和突触电流的幅度和动力学的变化。我们认为，后者的变化往往被忽视的网络行为的变化时，也有结构（连接）异常存在的来源;事实上，他们甚至可能会引起在这些国家观察到的结构变化。在这里，我们看看两个临床相关的状态（帕金森氏病和精神分裂症），并认为非结构性变化是重要的，在网络内的异常动态的发展，已知是相关的每种疾病。我们还讨论了麻醉，因为它是完全急性的，从而说明了在没有结构改变的情况下突触和内在膜电流变化的有效影响。在每一个这些，我们专注于微电路内的GABA能功能的变化的作用，强调在过去几年中的文献。

Dynamics of neuronal networks can be altered in at least two ways: by changes in connectivity, that is, the physical architecture of the network, or changes in the amplitudes and kinetics of the intrinsic and synaptic currents within and between the elements making up a network. We argue that the latter changes are often overlooked as sources of alterations in network behavior when there are also structural (connectivity) abnormalities present; indeed, they may even give rise to the structural changes observed in these states. Here we look at two clinically relevant states (Parkinson’s disease and schizophrenia) and argue that non-structural changes are important in the development of abnormal dynamics within the networks known to be relevant to each disorder. We also discuss anesthesia, since it is entirely acute, thus illustrating the potent effects of changes in synaptic and intrinsic membrane currents in the absence of structural alteration. In each of these, we focus on the role of changes in GABAergic function within microcircuits, stressing literature within the last few years.