CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway.
CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway.
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CENPA通过Wnt/β-catenin信号通路促进透明细胞肾细胞癌进展和转移
DOI：
10.1186/s12967-021-03087-8
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发表时间：
2021-10-09
影响因子：
7.4
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang Q;Xu J;Xiong Z;Xu T;Liu J;Liu Y;Chen J;Shi J;Shou Y;Yue C;Liu D;Liang H;Yang H;Yang X;Zhang X
Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in many types of cancers, but its functions in ccRCC have not been fully clarified. In this paper, we found that several CENP family members were highly expressed in ccRCC tissues. Also, CENPA expression level was related to clinicopathological grade and prognosis by weighted gene co-expression network analysis (WGCNA). CENPA served as a representative CENP family member as a ccRCC biomarker. Further in vitro experiments verified that overexpression of CENPA promoted ccRCC proliferation and metastasis by accelerating the cell cycle and activating the Wnt/β-catenin signaling pathway. The elevated β-catenin led by CENPA overexpression translocated to nucleus for downstream effect. Functional recovery experiment confirmed that Wnt/β-catenin pathway was essential for ccRCC progression and metastasis. Developing selective drugs targeting CENPA may be a promising direction for cancer treatment. The online version contains supplementary material available at 10.1186/s12967-021-03087-8.
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影响因子：
23.4
作者：
Moch, Holger;Cubilla, Antonio L.;Ulbright, Thomas M.
通讯作者：
Ulbright, Thomas M.
影响因子：
11.8
作者：
Funk LC;Zasadil LM;Weaver BA
通讯作者：
Weaver BA
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
影响因子：
5.6
作者：
Kruck S;Eyrich C;Scharpf M;Sievert KD;Fend F;Stenzl A;Bedke J
通讯作者：
Bedke J
影响因子：
6.6
作者：
Campbell, Steven;Uzzo, Robert G.;Pierorazio, Philip M.
通讯作者：
Pierorazio, Philip M.