Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease
Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease
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阿尔茨海默病的临床病史、脑代谢和神经心理功能
DOI：
10.1002/ana.410180305
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发表时间：
1985
影响因子：
11.2
通讯作者：
S. Rapoport
中科院分区：
文献类型：
--
作者：
N. Cutler;J. Haxby;R. Duara;C. Grady;A. Kay;R. Kessler;M. Sundaram;S. Rapoport
Data concerning 7 patients with a diagnosis of presumptive Alzheimer's disease (mean age, 65.6 years) are presented in detail in relation to the patients' regional cerebral metabolic rates for glucose. Rates were measured by positron emission tomography with fluorine 18–labeled fluoro‐2‐deoxy‐D‐glucose under conditions of reduced visual and auditory stimulation. A relationship was found between severity of dementia and brain metabolism. In patients with mild to moderate Alzheimer's disease, memory and intellectual deficits were evident without major reductions in absolute metabolic rates, while ratios of regional to whole brain metabolism revealed reductions in regions of the parietal lobes. In the late, severe form of the disease, brain metabolic rates were consistently and significantly reduced. The findings suggest that memory and intellectual deficits are reflected in reductions of brain metabolism in some brain regions in mild to moderate forms of Alzheimer's disease and that, in the late, severe form of the disease, reductions occur consistently throughout the brain.
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR
遗忘症的神经解剖学：杏仁核-海马与颞干。
DOI：
10.1126/science.6890713
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zola-Morgan,S;Squire,LR;Mishkin,M
通讯作者：
Mishkin,M