Striatal volumes in pediatric bipolar patients with and without comorbid ADHD.
Striatal volumes in pediatric bipolar patients with and without comorbid ADHD.
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DOI：
10.1016/j.pscychresns.2011.06.008
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发表时间：
2011-10-31
影响因子：
11.3
通讯作者：
Chang K
中科院分区：
文献类型：
--
作者：
Liu IY;Howe M;Garrett A;Karchemskiy A;Kelley R;Alegria D;Reiss A;Chang K
儿童双相情感障碍（BD）中最常见的合并症是注意力缺陷/多动障碍（ADHD）。由于尾状核体积异常已经在双相障碍和多动症中得到证实，本研究试图确定这些发现是否可以归因于两种诊断的可分离影响。获得4组青少年高分辨率解剖磁共振（MRI）图像：双相障碍合并ADHD （n = 17）、双相障碍未合并ADHD （n = 12）、单独ADHD青年（n = 11）和健康对照（n = 24）。每个受试者的尾状核、壳核和苍白球体积由一个不知道诊断的可靠评分者使用Brain Image Java软件手工追踪。纹状体体积的诊断有显著影响，ADHD与尾状核和壳核体积减少有关，BD与尾状核、壳核和苍白球体积增加有关。因此，双相障碍患者存在或不存在共病性ADHD与尾状核体积的明显改变相关，表明这两组具有不同但相关的神经病理机制。
The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n = 17), BD without comorbid ADHD (n = 12), youth with ADHD alone (n = 11), and healthy control subjects (n = 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using Brain Image Java software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.
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尾状反应的抑制是由尾状和丘脑介导的：功能性MRI和亨廷顿氏病的证据。
DOI：
10.1093/brain/awg067
发表时间：
2003-03
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Aron AR;Schlaghecken F;Fletcher PC;Bullmore ET;Eimer M;Barker R;Sahakian BJ;Robbins TW
通讯作者：
Robbins TW
影响因子：
0.8
作者：
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通讯作者：
Auer, A
影响因子：
4.5
作者：
Heitmiller, DR;Nopoulos, PC;Andreasen, NC
通讯作者：
Andreasen, NC
影响因子：
17.7
作者：
Lang, DJ;Kopala, LC;Honer, WG
通讯作者：
Honer, WG
影响因子：
4.8
作者：
Hajek, Tomas;Gunde, Eva;Aida, Martin
通讯作者：
Aida, Martin