Systematic changes in position sense accompany normal aging across adulthood.
Systematic changes in position sense accompany normal aging across adulthood.
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DOI：
10.1186/1743-0003-11-43
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发表时间：
2014-03-25
影响因子：
5.1
通讯作者：
Dukelow SP
中科院分区：
文献类型：
--
作者：
Herter TM;Scott SH;Dukelow SP
开发旨在区分正常与异常能力的临床神经学评估需要全面了解基本神经功能如何随着年龄的增长而变化（或不变化）。在本体感觉的情况下，研究文献未能最终确定老年人上肢的位置感是否恶化。本研究的目的是a）量化上肢位置感是否随年龄增长而恶化，以及B）生成一组可用于未来与临床人群进行比较的规范性数据。我们研究了209名年龄在18岁至90岁之间的健康男性和女性的位置感，使用机器人手臂位置匹配任务，这是客观和可靠的。在这项任务中，机器人将手臂移动到九个位置之一，受试者试图将该位置与另一个肢体镜像匹配。位置感的测量由机器人设备记录在基于手和关节的坐标中，并且线性回归被用于量化与年龄相关的变化和正常行为的百分位界限。对于临床比较，我们还研究了性别（男性与女性）和测试手（优势与非优势）对位置感的所有措施的影响。对基于手的参数的分析确定了位置感的几个测量指标（变异性、位移、空间收缩、绝对误差），这些指标受到年龄、性别和测试手的显着影响。肩部（绝对误差）和肘部（变异性、偏移、绝对误差）的关节参数也表现出年龄和测试手的显著影响。本研究提供了强有力的证据表明，上肢位置感的几个措施表现出随着年龄的增长而下降。此外，当位置感的变化与正常老化或病理学相关时，该数据提供了量化的基础。
Development of clinical neurological assessments aimed at separating normal from abnormal capabilities requires a comprehensive understanding of how basic neurological functions change (or do not change) with increasing age across adulthood. In the case of proprioception, the research literature has failed to conclusively determine whether or not position sense in the upper limb deteriorates in elderly individuals. The present study was conducted a) to quantify whether upper limb position sense deteriorates with increasing age, and b) to generate a set of normative data that can be used for future comparisons with clinical populations. We examined position sense in 209 healthy males and females between the ages of 18 and 90 using a robotic arm position-matching task that is both objective and reliable. In this task, the robot moved an arm to one of nine positions and subjects attempted to mirror-match that position with the opposite limb. Measures of position sense were recorded by the robotic apparatus in hand-and joint-based coordinates, and linear regressions were used to quantify age-related changes and percentile boundaries of normal behaviour. For clinical comparisons, we also examined influences of sex (male versus female) and test-hand (dominant versus non-dominant) on all measures of position sense. Analyses of hand-based parameters identified several measures of position sense (Variability, Shift, Spatial Contraction, Absolute Error) with significant effects of age, sex, and test-hand. Joint-based parameters at the shoulder (Absolute Error) and elbow (Variability, Shift, Absolute Error) also exhibited significant effects of age and test-hand. The present study provides strong evidence that several measures of upper extremity position sense exhibit declines with age. Furthermore, this data provides a basis for quantifying when changes in position sense are related to normal aging or alternatively, pathology.
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影响因子：
3.8
作者：
Aydog, ST;Korkusuz, P;Demirel, HA
通讯作者：
Demirel, HA
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1.5
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影响因子：
4.2
作者：
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