Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana.
Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana.
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DOI：
10.1101/gr.139873.112
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发表时间：
2013-01
期刊：
影响因子：
7
通讯作者：
Schlötterer C
中科院分区：
文献类型：
--
作者：
Nolte V;Pandey RV;Kofler R;Schlötterer C
尽管众所周知，选择塑造了果蝇的多态性模式，但经典选择性扫描的特征却很少。在这里，我们重点关注毛里求斯果蝇（Drosophila mauritiana），这是一种岛屿特有种，与黑腹果蝇（Drosophila melanogaster）密切相关。基于新的带注释的基因组序列，我们通过对汇集个体进行测序（Pool-seq）来表征全基因组多态性。我们表明，选择和重组之间的相互作用导致了 D. mauritiana 的全基因组多态性模式特征。两个大的基因组区域（> 500 kb）显示出几乎完全选择性扫描的特征。我们认为，缺乏种群结构和有限的地理分布可以解释为什么这种明显的扫描模式仅限于 D. mauritiana。在几个核孔蛋白基因中检测到了强适应性进化的进一步证据，其中一些基因以前未被识别为参与基因组冲突的基因。由于这种适应性进化在 D. mauritiana 和 Drosophila simulans 分裂后仍在继续，因此我们得出结论，基因组冲突并不局限于短暂的事件，而是果蝇中持续的过程。
Although it is well understood that selection shapes the polymorphism pattern in Drosophila, signatures of classic selective sweeps are scarce. Here, we focus on Drosophila mauritiana, an island endemic, which is closely related to Drosophila melanogaster. Based on a new, annotated genome sequence, we characterized the genome-wide polymorphism by sequencing pooled individuals (Pool-seq). We show that the interplay between selection and recombination results in a genome-wide polymorphism pattern characteristic for D. mauritiana. Two large genomic regions (>500 kb) showed the signature of almost complete selective sweeps. We propose that the absence of population structure and limited geographic distribution could explain why such pronounced sweep patterns are restricted to D. mauritiana. Further evidence for strong adaptive evolution was detected for several nucleoporin genes, some of which were not previously identified as genes involved in genomic conflict. Since this adaptive evolution is continuing after the split of D. mauritiana and Drosophila simulans, we conclude that genomic conflict is not restricted to short episodes, but rather an ongoing process in Drosophila.
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DOI：
10.1098/rstb.2000.0716
发表时间：
2000-11-29
影响因子：
6.3
作者：
Barton, NH
通讯作者：
Barton, NH
影响因子：
10.7
作者：
Bastide, Heloise;Cazemajor, Michel;Montchamp-Moreau, Catherine
通讯作者：
Montchamp-Moreau, Catherine
影响因子：
64.8
作者：
Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
通讯作者：
MacCallum, Iain
影响因子：
2.6
作者：
Colozza, Gabriele;Montembault, Emilie;Callaini, Giuliano
通讯作者：
Callaini, Giuliano
影响因子：
10.7
作者：
Derome, Nicolas;Baudry, Emmanuelle;Montchamp-Moreau, Catherine
通讯作者：
Montchamp-Moreau, Catherine