Autoimmunity and Graves' disease.

Autoimmunity and Graves' disease.
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DOI:
10.1038/clpt.2012.10
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发表时间:
2012-04
影响因子:
6.7
通讯作者:
--
中科院分区:
医学2区
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--
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目前格雷夫斯甲状腺功能亢进症和相关眼病(GO)的治疗选择并不一致有效,并伴有潜在的严重副作用。因此,人们一直致力于开发新的疗法。已经取得了进展,特别是在生产促甲状腺激素受体(TSHR)拮抗剂方面,作为单克隆阻断抗体或小分子配体。此外,利妥昔单抗(RTX)是第一个被研究用于治疗这些疾病的靶向生物疗法。
Current treatment options for Graves’ hyperthyroidism and the related ophthalmopathy (GO) are not uniformly effective and carry with them potentially serious side effects. As a result, efforts have been focused on the development of novel therapies. Progress has been made, particularly in the production of thyroid-stimulating hormone receptor (TSHR) antagonists, as either monoclonal blocking antibodies or small-molecule ligands. In addition, rituximab (RTX) is the first targeted biological therapy to be studied as treatment for these conditions.
DOI: 10.1210/jc.2010-1935
发表时间: 2011-02-01
影响因子: 5.8
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DOI: 10.1056/nejmra0905750
发表时间: 2010-02-25
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Bahn RS
通讯作者: Bahn RS