Complete genome sequence of soil actinobacteria Streptomyces cavourensis TJ430

Complete genome sequence of soil actinobacteria Streptomyces cavourensis TJ430
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土壤放线菌Streptomyces cavourensis TJ430全基因组序列

DOI:
10.1002/jobm.201800181
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发表时间:
2018-09
影响因子:
3.1
通讯作者:
王培培
王培培
中科院分区:
生物学4区
文献类型:
--
作者:
王培培

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从我国西南山区土壤中分离得到一新放线菌Streptomyces cavourensis TJ430。在前期研究中,TJ430表现出显着的杀菌活性和较强的抗生素产生能力。在这里,我们报告了该细菌的完整基因组,由 7.6 Mb 线性染色体和 0.2 Mb 质粒组成。预测染色体中有6450个基因,质粒中有225个基因,染色体上有12个基因岛。丰富的基因预测了抗生素代谢和应激抵抗的功能。 S. cavourensis TJ430、S. coelicolor A3(2) 和 S. lividans 66 的全基因组比较表明,TJ430 具有相对较高的菌株特异性。 16S rRNA系统发育树显示TJ430与S. cavourensis DSM40300具有高度同一性(99.79%)。 TJ430是一种新的、稀有的链霉菌属物种,对其基因组的分析有助于我们更好地了解该菌株的初级代谢机制以及进化生物学。
A new actinobacteria Streptomyces cavourensis TJ430 was isolated from the mountain soil collected from the southwest of China. In previous study, TJ430 showed striking bactericidal activities and strong ability of antibiotic production. Here, we report complete genome of this bacterium, consisting of 7.6 Mb linear chromosome and 0.2 Mb plasmids. It was predicted 6450 genes in chromosome and 225 genes in plasmids, as well as 12 gene islands in chromosome. Abundant genes have predicted functions in antibiotic metabolism and stress resistance. A whole‐genome comparison of S. cavourensis TJ430, S. coelicolor A3(2), and S. lividans 66 indicates that TJ430 has a relatively high degree of strain specificity. The 16S rRNA phylogenetic tree shows the high identities (99.79%) of TJ430 with S. cavourensis DSM40300. TJ430 is a new and rare Streptomyces species, and analysis of its genome helps us to better understand primary metabolism mechanism of this isolate, as well as the evolutionary biology.
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