Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.
Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.
复制标题
DOI：
10.1177/1055665620982754
复制
发表时间：
2021-10
影响因子：
1.1
通讯作者：
Frank-Ito, Dennis O.
中科院分区：
文献类型：
--
作者：
Shah, Reanna;Marcus, Jeffrey R.;Frank-Ito, Dennis O.
目的探讨单侧唇裂鼻畸形患者嗅隐窝混浊的程度。根据11名uCLND受试者（4名男性和7名女性）和7名正常受试者（3名男性和4名女性）的计算机断层扫描图像创建鼻气道解剖结构的受试者特异性三维重建。量化每个受试者单侧和双侧嗅区的体积和表面积，以评估混浊的影响。从定性上讲，75%-100%嗅隐窝混浊的患者被归类为极端，50%-75%为重度，25%-50%为中度，0%-25%为轻度。在11例uCLND受试者中，5例（45%）被归类为极重度嗅隐窝混浊，3例（27%）受试者为重度混浊，3例（27%）受试者为中度混浊。正常受试者的双侧嗅隐窝体积平均值（±标准差）显著大于uCLND受试者（0.9668 cm 3 ± 0.4061 cm 3 vs 0.3426 cm 3 ± 0.1316 cm 3; p<0.001）。此外，uCLND受试者的裂侧和非裂侧的单侧嗅觉空间体积显著小于正常解剖学受试者的单侧嗅觉体积（uCLND裂侧= 0.1623 cm 3 ± 0.0933 cm 3; uCLND非裂侧= 0.1803 cm 3 ± 0.0938 cm 3;正常= 0.4834 cm 3 ± 0.2328 cm 3; p<0.001）。我们的研究结果表明，与正常解剖结构的受试者相比，uCLND受试者中嗅隐窝混浊的患病率较高。大多数患有uCLND的受试者具有极端的嗅隐窝不透明，这可能会影响他们的嗅觉。
To evaluate the magnitude of olfactory recess opacity in patients with unilateral cleft lip nasal deformity (uCLND). Subject-specific three-dimensional reconstruction of the nasal airway anatomy was created from computed tomography images in 11 subjects (4 males and 7 females) with uCLND and 7 normal subjects (3 males, and 4 females). The volume and surface area of each subject’s unilateral and bilateral olfactory airspace was quantified to assess the impact of opacification. Qualitatively speaking, patients with 75%–100% olfactory recess opacification were classified as extreme, 50%–75% as severe, 25%–50% as moderate, and 0%–25% as mild. Of the 11 subjects with uCLND, 5 (45%) were classified as having extreme olfactory recess opacification, 3 (27%) subjects had severe opacification, and 3 (27%) subjects had moderate opacification. Mean ( ± standard deviation) bilateral olfactory recess volume was significantly greater in normal subjects than in subjects with uCLND (0.9668 cm3 ± 0.4061 cm3 versus 0.3426 cm3 ± 0.1316 cm3; p<0.001). Furthermore, unilateral olfactory airspace volumes for the cleft and non-cleft sides in subjects with uCLND were considerably less than unilateral olfactory volume in subjects with normal anatomy (uCLND cleft side = 0.1623 cm3 ± 0.0933 cm3; uCLND non-cleft side = 0.1803 cm3 ± 0.0938 cm3; normal = 0.4834 cm3 ± 0.2328 cm3; p<0.001). Our findings indicate a high prevalence of olfactory recess opacification among subjects with uCLND when compared to subjects with normal anatomy. The majority of subjects with uCLND had extreme olfactory recess opacity, which will likely influence their sense of smell.
登录
查看更多内容
影响因子：
2.6
作者：
Leopold, DA;Hummel, T;Kobal, G
通讯作者：
Kobal, G
影响因子：
1.7
作者：
Raviv, JR;Kern, RC
通讯作者：
Kern, RC
影响因子：
--
作者：
Santos, DV;Reiter, ER;Costanzo, RM
通讯作者：
Costanzo, RM
DOI：
10.1097/gox.0000000000002244
发表时间：
2019-05-01
影响因子：
1.5
作者：
Frank-Ito, Dennis O.;Carpenter, David J.;Marcus, Jeffrey R.
通讯作者：
Marcus, Jeffrey R.
影响因子：
--
作者：
Schiffman, Susan S;Zervakis, Jennifer
通讯作者：
Zervakis, Jennifer