Respiratory viruses and eosinophils: exploring the connections.
Respiratory viruses and eosinophils: exploring the connections.
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DOI：
10.1016/j.antiviral.2009.04.005
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发表时间：
2009-07
影响因子：
7.6
通讯作者：
Domachowske, Joseph B.
中科院分区：
文献类型：
--
作者：
Rosenberg, Helene F.;Dyer, Kimberly D.;Domachowske, Joseph B.
在这篇综述中，我们考虑嗜酸性白细胞在呼吸道病毒感染的发病机制和病理生理中所起的作用。关于这一主题的绝大多数现有信息都集中在呼吸道合胞病毒（RSV；副粘病毒科，肺炎病毒属），这是一种感染全世界婴儿的重要儿科病原体。目前尚无针对呼吸道合胞病毒的疫苗。在20世纪60年代的一项试验中使用的福尔马林灭活的RSV疫苗引起了对自然RSV感染的免疫病理反应；这已经在实验中建立了模型，主要是在近亲繁殖的小鼠和棉花大鼠身上。在人类和实验模型中，嗜酸性粒细胞被募集到肺组织以响应福尔马林灭活的RSV疫苗抗原，但它们可能参与也可能不参与促进所观察到的严重临床后遗症。对原发性RSV感染引起的肺嗜酸性粒细胞增多也进行了探讨；这种反应在最小的人类婴儿和新生小鼠模型中尤为明显。尽管肺嗜酸性粒细胞几乎总是被认为是阴性的，但病毒引起的嗜酸性粒细胞（阴性、阳性或中性旁观者）所起的具体作用仍不清楚。最后，我们考虑了关注嗜酸性粒细胞在促进病毒清除和抗病毒宿主防御中的作用的数据，并总结了最近的一项研究，探讨了嗜酸性粒细胞本身作为病毒感染靶点的作用。
In this review, we consider the role played by eosinophilic leukocytes in the pathogenesis and pathophysiology of respiratory virus infection. The vast majority of the available information on this topic focuses on respiratory syncytial virus (RSV; Family Paramyxoviridae, genus Pneumovirus), an important pediatric pathogen that infects infants worldwide. There is no vaccine currently available for RSV. A formalin-inactivated RSV vaccine used in a trial in the 1960s elicited immunopathology in response to natural RSV infection; this has been modeled experimentally, primarily in inbred mice and cotton rats. Eosinophils are recruited to the lung tissue in response to formalin-inactivated RSV vaccine antigens in humans and in experimental models, but they may or may not be involved in promoting the severe clinical sequelae observed. Pulmonary eosinophilia elicited in response to primary RSV infection has also been explored; this response is particularly evident in the youngest human infants and in neonatal mouse models. Although pulmonary eosinophilia is nearly always perceived in a negative light, the specific role played by virus-elicited eosinophils – negative, positive or neutral bystander – remain unclear. Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection.
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影响因子：
14.2
作者：
Castro, Mario;Schweiger, Toni;Yin-DeClue, Huiquing;Ramkumar, Thiruvamoor P.;Christie, Chandrika;Zheng, Jie;Cohen, Rebecca;Schechtman, Kenneth B.;Strunk, Robert;Bacharier, Leonard B.
通讯作者：
Bacharier, Leonard B.
DOI：
10.4049/jimmunol.181.10.6692
发表时间：
2008-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castilow EM;Legge KL;Varga SM
通讯作者：
Varga SM
影响因子：
5.4
作者：
Barata, LT;Ying, S;Kay, AB
通讯作者：
Kay, AB
DOI：
10.1165/ajrcmb.23.5.3771
发表时间：
2000-11-01
影响因子：
6.4
作者：
Barr, FE;Pedigo, H;Shepherd, VL
通讯作者：
Shepherd, VL
影响因子：
4.4
作者：
Dakhama, A;Park, JW;Gelfand, EW
通讯作者：
Gelfand, EW