CDD: specific functional annotation with the Conserved Domain Database.
CDD: specific functional annotation with the Conserved Domain Database.
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DOI：
10.1093/nar/gkn845
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发表时间：
2009-01
影响因子：
14.9
通讯作者：
Bryant SH
中科院分区：
文献类型：
--
作者：
Marchler-Bauer A;Anderson JB;Chitsaz F;Derbyshire MK;DeWeese-Scott C;Fong JH;Geer LY;Geer RC;Gonzales NR;Gwadz M;He S;Hurwitz DI;Jackson JD;Ke Z;Lanczycki CJ;Liebert CA;Liu C;Lu F;Lu S;Marchler GH;Mullokandov M;Song JS;Tasneem A;Thanki N;Yamashita RA;Zhang D;Zhang N;Bryant SH
NCBI的保守结构域数据库（Conserved Domain Database，CDD）是一个多序列比对和衍生数据库搜索模型的集合，其代表了分子进化中保守的蛋白质结构域。该集合可以在http：//www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml上访问，并且也是NCBI的Cockz查询和检索系统的一部分，与许多其他资源交叉链接。CDD提供蛋白质序列上的结构域足迹和保守功能位点的注释。可以检索NCBI的MSPZ系统中跟踪的蛋白质序列的预先计算的结构域注释，并且可以通过http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi上的CD-Search服务用新蛋白质序列查询CDD的模型集合。从最新版本的CDD v2.14开始，在超家族水平上总结了来自冗余和同源结构域模型的信息，并且蛋白质上的结构域注释被标记为“特异性”（以高置信度识别分子功能）或“非特异性”（仅识别超家族成员）。
NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, cross-linked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either ‘specific’ (identifying molecular function with high confidence) or as ‘non-specific’ (identifying superfamily membership only).
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影响因子：
14.9
作者：
Wheeler, David L.;Barrett, Tanya;Benson, Dennis A.;Bryant, Stephen H.;Canese, Kathi;Chetvernin, Vyacheslav;Church, Deanna M.;DiCuccio, Michael;Edgar, Ron;Federhen, Scott;Feolo, Michael;Geer, Lewis Y.;Helmberg, Wolfgang;Kapustin, Yuri;Khovayko, Oleg;Landsman, David;Lipman, David J.;Madden, Thomas L.;Maglott, Donna R.;Miller, Vadim;Ostell, James;Pruitt, Kim D.;Schuler, Gregory D.;Shumway, Martin;Sequeira, Edwin;Sherry, Steven T.;Sirotkin, Karl;Souvorov, Alexandre;Starchenko, Grigory;Tatusov, Roman L.;Tatusova, Tatiana A.;Wagner, Lukas;Yaschenko, Eugene
通讯作者：
Yaschenko, Eugene
影响因子：
14.9
作者：
Andreeva, Antonina;Howorth, Dave;Chandonia, John-Marc;Brenner, Steven E.;Hubbard, Tim J. P.;Chothia, Cyrus;Murzin, Alexey G.
通讯作者：
Murzin, Alexey G.
影响因子：
14.9
作者：
Marchler-Bauer, A;Anderson, JB;Bryant, SH
通讯作者：
Bryant, SH
影响因子：
7
作者：
Geer, LY;Domrachev, M;Bryant, SH
通讯作者：
Bryant, SH
影响因子：
14.9
作者：
Finn, Robert D.;Tate, John;Bateman, Alex
通讯作者：
Bateman, Alex