Dynamic Changes in Coagulation Function in Patients With Pneumonia Under Admission and Non-admission Treatment.
Dynamic Changes in Coagulation Function in Patients With Pneumonia Under Admission and Non-admission Treatment.
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入院及非入院治疗期间肺炎患者凝血功能的动态变化
DOI：
10.3389/fmed.2021.626384
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发表时间：
2021
影响因子：
3.9
通讯作者：
Qiu J
中科院分区：
文献类型：
--
作者：
Xu J;Zhang Y;Li Y;Liao K;Zeng X;Zeng X;Meng R;Zhou W;Wang K;Gong Y;Hua F;Xu J;Qiu J
目的：探讨入院和非入院治疗的肺炎患者凝血功能的动态变化以及年龄对凝血功能的影响。方法：我们纳入了华中科技大学附属武汉协和医院（中国武汉）的 178 名确诊的 COVID-19 成年住院患者。患者分为普通型，住院后均痊愈出院。我们记录患者首次出现临床症状的时间，并在入院时和入院后进行凝血检查。总共分析了八个因素（TT、FIB、INR、APTT、PT、DD、ATIII 和 FDP）。根据首次症状出现至入院时间将患者分为四组进行比较分析。对发病2周内入院的患者进行凝血试验动态变化分析。根据患者年龄是否大于或小于55岁，进一步分为两组，一组为发病后2周内入院的患者，另一组为发病后2周内入院的患者。采用卡方检验和T检验探讨凝血功能的动态变化以及年龄对凝血功能测试结果的影响。结果：共纳入178例住院患者，其中34例接受动态检测。我们根据COVID-19肺炎发病与入院时间之间的时间间隔将这些患者分为四组：1-7天（第1组）、8-14天（第2组）、15-21天（第3组）和>21天（第4组）。 8个因素均在发病后2周内升高，并在患者入院前2周逐渐下降至正常。入院患者的凝血功能变化相似。入院后，8个因素中下降最显着的是第2周至第3周。55岁以上人群与55岁以下人群中8个因素之间存在明显差异。入院后前2周，>55岁患者的8个因子水平显着高于<55岁患者，再治疗2周后，两个年龄组的因子水平均恢复正常。结论：无论治疗如何，8个因素在发病后2周内均升高，2周后逐渐下降至正常。与55岁以下患者相比，55岁以上患者的凝血检测值变化较大。
Objective: We aimed to explore the dynamic changes in coagulation function and the effect of age on coagulation function in patients with pneumonia under admission and non-admission treatment. Methods: We included 178 confirmed adult inpatients with COVID-19 from Wuhan Union Hospital Affiliated to Huazhong University of Science and Technology (Wuhan, China). Patients were classified into common types, and all were cured and discharged after hospitalization. We recorded the time of the first clinical symptoms of the patients and performed blood coagulation tests at the time of admission and after admission. In total, eight factors (TT, FIB, INR, APTT, PT, DD, ATIII, and FDP) were analyzed. Patients were classified into four groups according to the time from the first symptom onset to hospital admission for comparative analysis. The patients who were admitted within 2 weeks of disease onset were analyzed for the dynamic changes in their blood coagulation tests. Further division into two groups, one group comprising patients admitted to the hospital within 2 weeks after the onset of disease and the other comprising patients admitted to the hospital 2 weeks after disease onset, was performed to form two groups based on whether the patient ages were over or under 55 years. Chi-square tests and T tests were used to explore the dynamic changes in coagulation function and the influence of age on the results of coagulation function tests. Results: A total of 178 inpatients, 34 of whom underwent dynamic detection, were included in this analysis. We divided these patients into four groups according to the interval between the onset of COVID-19 pneumonia and the time to admission in the hospital: the 1–7 days (group 1), 8–14 days (group 2), 15–21 days (group 3), and >21-days (group 4). Eight factors all increased within 2 weeks after onset and gradually decreased to normal 2 weeks before the patient was admitted. The changes in coagulation function of patients admitted to the hospital were similar. After being admitted to the hospital, the most significant decreases among the eight factors were between week 2 and 3. There were distinct differences among the eight factors between people older than 55 years and those younger than 55 years. In the first 2 weeks after being admitted, the levels of the eight factors in patients >55 years were significantly higher than those in patients <55 years, and after another 2 weeks of treatment, the factor levels in both age groups returned to normal. Conclusion: The eight factors all increased within 2 weeks after onset and gradually decreased to normal after 2 weeks regardless of treatment. Compared with patients younger than 55 years, patients older than 55 years have greater changes in their blood coagulation test values.
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影响因子：
3.8
作者：
Karhu J;Ala-Kokko TI;Vuorinen T;Ohtonen P;Julkunen I;Syrjälä HT
通讯作者：
Syrjälä HT
影响因子：
5.7
作者：
Milbrandt, Eric B.;Reade, Michael C.;Kellum, John A.
通讯作者：
Kellum, John A.
影响因子：
8.8
作者：
Rijneveld, Anita W.;Weijer, Sebastiaan;van der Poll, Tom
通讯作者：
van der Poll, Tom
影响因子：
10
作者：
Chan, JWM;Ng, CK;Li, PCK
通讯作者：
Li, PCK
DOI：
10.1165/ajrcmb.22.4.f184
发表时间：
2000-04-01
影响因子：
6.4
作者：
Abraham, E
通讯作者：
Abraham, E