A Multicenter Validation of Regional Cerebral Blood Flow Quantitation Using [123I]Iodoamphetamine and Single Photon Emission Computed Tomography
A Multicenter Validation of Regional Cerebral Blood Flow Quantitation Using [123I]Iodoamphetamine and Single Photon Emission Computed Tomography
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使用[123I]碘苯丙胺和单光子发射计算机断层扫描对区域脑血流定量进行多中心验证
DOI：
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发表时间：
1996
影响因子：
6.3
通讯作者：
K. Uemura
中科院分区：
文献类型：
--
作者：
H. Iida;Tooru Akutsu;K. Endo;Hiroshi Fukuda;T. Inoue;H. Ito;S. Koga;A. Komatani;Y. Kuwabara;T. Momose;S. Nishizawa;I. Odano;M. Ohkubo;Y. Sasaki;H. Suzuki;Shuuji Tanada;H. Toyama;Y. Yonekura;Tsuyoshi Yoshida;K. Uemura
最近，已经提出了两种方法用于局部脑血流量（rCBF）定量使用[123 I]碘苯丙胺（IMP）和单光子发射计算机断层扫描（SPECT）。查表（TLU）方法已被证明可以提供两次SPECT扫描的rCBF和分布容积（Vd）图像，而单次扫描放射自显影（ARG）技术使用固定和假设的Vd提供rCBF。在这两种方法中，一个单一的血液样本被称为校准先前确定的标准输入函数。本多中心项目的目的是评估这两种方法的准确性，用作临床研究工具。10个独立机构根据两种方法对76名受试者（10名正常志愿者，32名脑血管疾病患者和34名其他疾病患者）进行了[123 I]IMP-SPECT研究。将计算的rCBF值与参与机构中可用的以下参考方法获得的值进行比较：[15 O] H2O正电子发射断层扫描（PET）（5个机构），[133 I]SPECT（4个机构）和[123 I]IMP微球方法（3个机构）。ARG和TLU方法提供的rCBF值与[15 O] H2O PET技术测量的值（所有受试者p < 0.001;总体回归方程，y = 15.14 + 0.54×）和[123 I] IMP-微球方法测量的值（所有受试者p < 0.001; y = 2.0 + 0.80×）显著相关。在24名受试者中，有18名受试者采用[133 <$] SPECT参考技术（总体回归方程，y = 15.0 + 0.55×）进行了研究，观察到显著相关性（p < 0.05）。一组正常受试者的ARG和TLU方法的平均皮质灰质rCBF分别为43.9 ± 3.3和43.4 ± 2.0 ml/min/100 g。在正常皮质区，通过TLU方法估计的[123 I]IMP的局部Vd为45 ml/ml ± 20%。观察到ARG和TLU rCBF值之间非常一致（y = −3.21 + 1.07×，r = 0.97），证实了ARG方法中假设Vd固定的有效性。本研究的结果表明，ARG和TLU方法在各种临床环境中准确可靠地估计rCBF。
Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [123I]iodoamphetamine (IMP) and single-photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution, Vd, images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed Vd. In both methods, a single blood sample was referred to calibrate the previously determined standard input function The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [123I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions; [15O] H2O positron emission tomography (PET) (five institutions), [133Xe]SPECT (four institutions), and the [123I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p < 0.001 for all subjects; overall regression equation, y = 15.14 + 0.54×) and those measured by the [123I]IMP-microsphere method (p < 0.001 for all subjects; y = 2.0 + 0.80×). Significant correlation (p < 0.05) was observed in 18 of 24 subjects studied with the [133Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55×). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 ml/min/100 g for the ARG and TLU methods, respectively. Regional Vd of [123I]IMP estimated by the TLU method was 45 ml/ml ± 20% in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = −3.21 + 1.07×, r = 0.97), confirming the validity of assuming a fixed Vd in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.
使用 133 氙吸入法进行肺外监测与呼气末空气检测的比较。
影响因子：
8.3
作者：
Hazelrig,JB;HalseyJr,JH;Wilson,EM;Wills,EL
通讯作者：
Wills,EL
DOI：
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发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
使用发射断层扫描对碘-123-碘苯丙胺作为脑血流示踪剂进行验证研究。
DOI：
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发表时间：
1990
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Greenberg,JH;Kushner,M;Rango,M;Alavi,A;Reivich,M
通讯作者：
Reivich,M