The effect of the ectoderm on the dorsoventral pattern of epidermis, muscles and joints in the developing chick leg: a new model
The effect of the ectoderm on the dorsoventral pattern of epidermis, muscles and joints in the developing chick leg: a new model
复制标题
外胚层对发育中的鸡腿表皮、肌肉和关节背腹模式的影响：一个新模型
DOI：
10.1007/bf00186694
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Akita
中科院分区：
文献类型：
--
作者：
K. Akita
为了研究外胚层对鸡腿中胚层成分模式的影响，将早期肢芽的外胚层与中胚层背腹颠倒。通过肌肉、骨骼和表皮分化的检查来评估背腹型。重组体形成越早，四肢中胚层的背腹向外胚层的逆转越彻底，远端的逆转比近端的完全。对腿背腹侧模式的分析表明，背侧化从背侧外胚层开始，影响中胚层结构，从中线向中线再到腹侧外胚层。软骨、肌肉和表皮的背腹型之间没有严格的一致性。结果表明，在腹侧外胚层影响背侧中胚层之前，来自背侧外胚层的信号改变了腹侧中胚层。这些关于中胚层对外胚层逆转的反应方式的观察提出了一个新的模型。该模型基于两个不同的信号，均始于进展区：(1)由背侧外胚层构成的因子，它指定背侧状态与腹侧状态不同；(2)来自顶端外胚层脊的对称位置信号，它沿着背腹轴排列组织。
In order to investigate the effect of the ectoderm on the pattern of mesodermal components in the chick leg, the ectoderm of the early limb bud was dorsoventrally reversed with respect to the mesoderm. The dorsoventral pattern was assessed by examination of the muscles, skeleton and epidermal differentiation. The earlier the stage at which the recombinants were made, the more complete was the reversal of the dorsoventral pattern of the limb mesoderm to conform with the ectoderm, and distal regions showed more complete reversals than proximal ones. Analysis of dorsoventral pattern along the leg shows that the dorsalization starts from the dorsal ectoderm and affects mesodermal structures in its progress to the midline and then to the ventral ectoderm. There was no strict congruence between the dorsoventral patterns of cartilage, muscle and epidermis. The results suggest that a signal from the dorsal ectoderm modifies ventral mesoderm before ventral ectoderm affects dorsal mesoderm. These observations about the way in which the mesoderm responds to ectoderm reversal suggest a new model. The model is based on two distinct signals, both initiated within the progress zone: (1) a factor made by dorsal ectoderm which specifies a dorsal state as distinct from a ventral state, and (2) a symmetrical positional signal from the apical ectodermal ridge which patterns the tissues along the dorsoventral axis.
Lbx1 表达和青蛙肢体发育。
影响因子：
2.4
作者：
Sabo,MichelleC;Nath,Kimberly;Elinson,RichardP
通讯作者：
Elinson,RichardP
影响因子：
56.9
作者：
FALLON, JF;LOPEZ, A;SIMANDL, BK
通讯作者：
SIMANDL, BK