Systemic inflammation after spinal cord injury: A review of biological evidence, related health risks, and potential therapies.
Systemic inflammation after spinal cord injury: A review of biological evidence, related health risks, and potential therapies.
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DOI：
10.1016/j.coph.2022.102303
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发表时间：
2022-12
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
患有慢性创伤性脊髓损伤（SCI）的个体发展出渐进性多系统健康问题，导致临床疾病和残疾。全身炎症与许多常见的医学并发症和慢性SCI伴随的获得性疾病相关，这表明它有助于许多共病的病理条件。然而，许多促进持续性全身炎症及其后果的机制仍然不明确。本文综述了导致全身性炎症的重要生物学因素、受影响的主要器官系统、健康风险以及潜在的治疗策略。我们的目的是强调需要更好地了解炎症过程，并建立适当的策略，以解决SCI炎症。
Individuals with chronic traumatic spinal cord injury (SCI) develop progressive multi-system health problems that result in clinical illness and disability. Systemic inflammation is associated with many of the common medical complications and acquired diseases that accompany chronic SCI, suggesting that it contributes to a number of comorbid pathological conditions. However, many of the mechanisms that promote persistent systemic inflammation and its consequences remain ill-defined. This review describes the significant biological factors that contribute to systemic inflammation, major organ systems affected, health risks, and the potential treatment strategies. We aim to highlight the need for a better understanding of inflammatory processes, and to establish appropriate strategies to address inflammation in SCI.
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影响因子：
2.1
作者：
Garshick, Eric;Stolzmann, Kelly L.;Gagnon, David R.;Morse, Leslie R.;Brown, Robert
通讯作者：
Brown, Robert
影响因子：
9.3
作者：
Allison, David J.;Ditor, David S.
通讯作者：
Ditor, David S.
DOI：
10.1682/jrrd.2014.02.0060
发表时间：
2015-01-01
影响因子：
--
作者：
Asselin, Pierre;Knezevic, Steven;Spungen, Ann M.
通讯作者：
Spungen, Ann M.
影响因子：
6.3
作者：
Abulafia, Denise P.;Vaccari, Juan Pablo de Rivero;Dietrich, W. Dalton
通讯作者：
Dietrich, W. Dalton
DOI：
10.1016/j.pmrj.2017.08.437
发表时间：
2018-03
期刊：
PM & R : the journal of injury, function, and rehabilitation
影响因子：
--
作者：
Garshick E;Walia P;Goldstein RL;Teylan M;Lazzari AA;Tun CG;Hart JE
通讯作者：
Hart JE