Systemic inflammation and reduced pulmonary function in chronic spinal cord injury.
Systemic inflammation and reduced pulmonary function in chronic spinal cord injury.
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DOI：
10.1016/j.pmrj.2011.02.003
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发表时间：
2011-05
期刊：
影响因子：
2.1
通讯作者：
Brown, Robert
中科院分区：
文献类型：
--
作者：
Garshick, Eric;Stolzmann, Kelly L.;Gagnon, David R.;Morse, Leslie R.;Brown, Robert
探讨慢性脊髓损伤（SCI）患者全身炎症反应与肺功能的关系。横断面研究。退伍军人事务医疗中心59名慢性SCI男性参与既往流行病学研究。肺功能标准化评估及血浆C反应蛋白（CRP）和白细胞介素-6（IL-6）测定。1秒用力呼气量（FEV 1）和用力肺活量（FVC）。IL-6值最高的人FEV 1和FVC %预测值最低。IL-6四分位数与FEV 1预测值百分比（P < .001）和FVC（P < .006）之间存在显著的负线性趋势，未校正和校正SCI水平和损伤完整性、阻塞性肺疾病史、吸烟和体重指数（P = .010-.039）。尽管不如IL-6那么强，但FEV 1预测百分比和FVC与CRP也存在类似的趋势。在慢性SCI中，较高水平的IL-6和CRP与较低的FEV 1和FVC相关，与损伤的水平和完整性无关。这些结果表明，脊髓损伤后肺功能的降低不仅与神经肌肉损伤有关，而且与促进全身炎症的因素有关。
To evaluate the relationship between systemic inflammation and pulmonary function in persons with chronic spinal cord injury (SCI). Cross-sectional study. Veterans Affairs Medical Center. Fifty-nine men with chronic SCI participating in a prior epidemiologic study. Standardized assessment of pulmonary function and measurement of plasma C-reactive protein (CRP) and interleukin-6 (IL-6). Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). Persons with the highest values of IL-6 had the lowest %-predicted FEV1 and FVC. There was a significant inverse linear trend between quartile of IL-6 and %-predicted FEV1 (P < .001) and FVC (P < .006), unadjusted and adjusted for SCI level and completeness of injury, obstructive lung disease history, smoking, and body mass index (P = .010-.039). Although not as strong as for IL-6, there also were similar trends for %-predicted FEV1 and FVC with CRP. In chronic SCI, higher levels of IL-6 and CRP were associated with a lower FEV1 and FVC, independent of level and completeness of injury. These results suggest that the reduction of pulmonary function after SCI is related not only to neuromuscular impairment but also to factors that promote systemic inflammation.
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DOI：
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影响因子：
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