Gender differences in Parkinson's disease: clinical characteristics and cognition.
Gender differences in Parkinson's disease: clinical characteristics and cognition.
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DOI：
10.1002/mds.23388
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发表时间：
2010-12-15
影响因子：
8.6
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Miller, Ivy N.;Cronin-Golomb, Alice
更多的男性比女性被诊断患有帕金森病（PD），并且在这种疾病中有一些性别差异。男性比女性更常出现的临床特征的例子包括僵硬和快速眼动行为障碍，而女性比男性表现出运动障碍和抑郁。男性和女性在认知方面的差异尚未得到广泛研究，尽管有报告称，男性在日常生活活动、语言流畅性和面部情绪识别方面存在认知缺陷，女性在视觉空间认知方面存在缺陷。发病侧可能与性别相互作用，影响认知能力。PD的临床和认知特征的男女差异的一个可能来源是雌激素对大脑中多巴胺能神经元和通路的影响。这种影响尚未被理解，因为目前对雌激素在一生中的波动如何影响大脑的了解有限。进一步关注这一领域的研究将是重要的准确评估和更好的管理PD。还应注意可能影响临床特征和认知的多个协变量。了解男性和女性PD症状表现的差异以及这些差异背后的病理生理学可能会提高疾病临床评估和治疗的准确性和有效性。
More men than women are diagnosed with Parkinson's disease (PD), and a number of gender differences have been documented in this disorder. Examples of clinical characteristics that appear in men more often than women include rigidity and rapid eye movement behavior disorder, whereas more women than men exhibit dyskinesias and depression. Differences between men and women in cognition have not been extensively examined, though there are reports of deficits in men in aspects of cognition that contribute to activities of daily living, in verbal fluency, and in the recognition of facial emotion, and deficits in women in visuospatial cognition. Side of disease onset may interact with gender to affect cognitive abilities. One possible source of male-female differences in the clinical and cognitive characteristics of PD is the effect of estrogen on dopaminergic neurons and pathways in the brain. This effect is not yet understood, as insight into how the fluctuation of estrogen over the lifetime affects the brain is currently limited. Further attention to this area of research will be important for accurate assessment and better management of PD. Attention should also be directed to multiple covariates that may affect clinical characteristics and cognition. Knowledge about differences in the presentation of PD symptoms in men and women and about the pathophysiology underlying those differences may enhance the accuracy and effectiveness of clinical assessment and treatment of the disease.
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影响因子：
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