Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.
Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.
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DOI：
10.1016/j.biopsych.2017.01.003
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发表时间：
2017-11-01
影响因子：
10.6
通讯作者：
Potter AS
中科院分区：
文献类型：
--
作者：
Albaugh MD;Orr C;Chaarani B;Althoff RR;Allgaier N;D'Alberto N;Hudson K;Mackey S;Spechler PA;Banaschewski T;Brühl R;Bokde ALW;Bromberg U;Büchel C;Cattrell A;Conrod PJ;Desrivières S;Flor H;Frouin V;Gallinat J;Goodman R;Gowland P;Grimmer Y;Heinz A;Kappel V;Martinot JL;Paillère Martinot ML;Nees F;Orfanos DP;Penttila J;Poustka L;Paus T;Smolka MN;Struve M;Walter H;Whelan R;Schumann G;Garavan H;Potter AS
注意力缺陷/多动障碍 (ADHD) 的神经影像学研究最常报道基底神经节、小脑和前额皮质的体积异常。很少有研究在人群样本中检验多动症症状与大脑结构之间的关系。在此，我们研究了多动症症状的维度测量、大脑结构和反应时间变异性（注意力缺失的指标）之间的关系。我们还测试了 ADHD 症状的大脑结构相关性与多巴胺能基因表达图谱之间的关联。可获得 1,538 名青少年的精神病理学和影像学数据。家长对 ADHD 症状的评分是通过发展和健康评估 (DAWBA) 以及优势和困难问卷 (SDQ) 获得的。使用青年版 SDQ 评估 ADHD 症状的自我报告。一部分参与者存在反应时间变异性。对于每项测量，都计算了灰质体积 (GMV) 的全脑体素回归。家长对 ADHD 症状的评分（DAWBA 和 SDQ）、青少年在 SDQ 上自我报告的 ADHD 症状以及反应时间变异性均与腹内侧前额叶皮质 (vmPFC) 重叠区域的 GMV 呈负相关。 DRD1 和 DRD2 基因表达图谱与 ADHD 症状的大脑结构相关。这是第一项在大量青少年人群样本中揭示 vmPFC 结构与 ADHD 症状多信息测量之间关系的研究。我们的结果表明 vmPFC 结构是 ADHD 症状的生物标志物。这些发现扩展了先前关于 ADHD 中默认模式网络和多巴胺能功能障碍的研究。
Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. Herein, we investigate the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability—an index of lapses in attention. We also test for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression. Psychopathology and imaging data were available for 1,538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment (DAWBA) and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptomatology were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole brain voxel-wise regressions with gray matter volume (GMV) were calculated. Parent ratings of ADHD symptoms (DAWBA and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with GMV in an overlapping region of the ventromedial prefrontal cortex (vmPFC). Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology. This is the first study to reveal relations between vmPFC structure and multi-informant measures of ADHD symptomatology in a large population-based sample of adolescents. Our results indicate that vmPFC structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.
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影响因子：
2.3
作者：
Depue, Brendan E.;Burgess, Gregory C.;Bidwell, L. Cinnamon;Willcutt, Erik G.;Banich, Marie T.
通讯作者：
Banich, Marie T.
影响因子：
2.6
作者：
Bellgrove, MA;Hester, R;Garavan, H
通讯作者：
Garavan, H
影响因子：
7.6
作者：
HALL, H;SEDVALL, G;FARDE, L
通讯作者：
FARDE, L
影响因子：
3.1
作者：
Hudziak, James J.;Achenbach, Thomas M.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
3
作者：
Almeida Montes, Luis Guillermo;Ricardo-Garcell, Josefina;Fernandez Bouzas, Antonio
通讯作者：
Fernandez Bouzas, Antonio