Inflammatory and mental health sequelae of COVID-19.
Inflammatory and mental health sequelae of COVID-19.
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Covid-19的炎症和心理健康后遗症。
DOI：
10.1016/j.cpnec.2023.100186
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发表时间：
2023-08
影响因子：
--
通讯作者：
Moorman, Jonathan
中科院分区：
文献类型：
--
作者：
Loftis, Jennifer M.;Firsick, Evan;Shirley, Kate;Adkins, James L.;Sano, Emily;Hudson, Rebekah;Moorman, Jonathan
新冠肺炎大流行对心理健康造成了重大负面后果。炎症因素和神经精神症状的增加，如认知障碍(“脑雾”)、抑郁和焦虑与长COVID[SARS-CoV-2感染的急性后遗症，称为神经性PASC]有关。目前的研究试图在新冠肺炎的背景下检查炎症因素作为神经精神症状严重程度预测因子的作用。新冠肺炎检测呈阴性或阳性的成年人(n=52)被要求完成自我报告问卷，并提供血样进行多重免疫分析。对新冠肺炎检测为阴性的参与者进行基线评估和后续研究访问(4周后的∼)。与基线相比，没有新冠肺炎的个体在随访时的PHQ-4得分显著降低(P=0.03；−0.084的95%CI-1.67)。新冠肺炎检测呈阳性并经历过神经PASC的患者PHQ-4得分处于中等范围。大多数患有神经性PASC的人报告经历了脑雾(70%对30%)。重度新冠肺炎患者的PHQ4评分显著高于轻度患者(P=0.008；95%CI为1.32~7.97)。神经精神症状严重程度的变化伴随着免疫因素的变化，特别是干扰素(干扰素-γ)诱导的单核细胞因子(MIG，又名。CXCL9)。这些发现增加了越来越多的证据，支持循环MIG水平作为反映干扰素-γ产生的生物标记物的有用性，这一点很重要，因为患有神经性帕金森病的人对内部SARS-CoV-2蛋白的干扰素-γ反应增强。新冠肺炎检测呈阴性的成年人焦虑症状的严重程度随着时间的推移而减轻。在新冠肺炎阴性的成年人中，焦虑程度降低伴随着炎症因子的减少。患有神经性PASC的成年人抑郁评分在中-重度范围内。患有更严重新冠肺炎的成年人报告说，他们的抑郁程度明显更高。新冠肺炎病情越重，干扰素-γ诱导的血浆单核细胞因子水平越高。
The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]. The present study sought to examine the role of inflammatory factors as predictors of neuropsychiatric symptom severity in the context of COVID-19. Adults (n = 52) who tested negative or positive for COVID-19 were asked to complete self-report questionnaires and to provide blood samples for multiplex immunoassays. Participants who tested negative for COVID-19 were assessed at baseline and at a follow-up study visit (∼4 weeks later). Individuals without COVID-19 reported significantly lower PHQ-4 scores at the follow-up visit, as compared to baseline (p = 0.03; 95% CI-1.67 to −0.084). Individuals who tested positive for COVID-19 and experienced neuro-PASC had PHQ-4 scores in the moderate range. The majority of people with neuro-PASC reported experiencing brain fog (70% vs. 30%). Those with more severe COVID-19 had significantly higher PHQ-4 scores, as compared to those with mild disease (p = 0.008; 95% CI 1.32 to 7.97). Changes in neuropsychiatric symptom severity were accompanied by alterations in immune factors, particularly monokine induced by gamma interferon (IFN-γ) (MIG, a. k.a. CXCL9). These findings add to the growing evidence supporting the usefulness of circulating MIG levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-PASC have elevated IFN-γ responses to internal SARS-CoV-2 proteins. Severity of anxiety symptoms reduced over time in adults who tested negative for COVID-19. In adults negative for COVID-19, less anxiety was accompanied by decreases in inflammatory factors. Adults with neuro-PASC had depression scores in the moderate-severe range. Adults with more severe COVID-19 reported significantly greater depression. Adults with more severe COVID-19 had higher plasma levels of monokine induced by interferon gamma.
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影响因子：
3.7
作者：
Saeed, Banaz;Ismael, Saween A.;Amin, Redar Muhmed P.;Mahmud, Nasraw Mustafa;Al-Banna, Dara;Shabila, Nazar
通讯作者：
Shabila, Nazar
影响因子：
3.1
作者：
Camacho-Arroyo I;Flores-Ramos M;Mancilla-Herrera I;Cruz FMC;Hernández-Ruiz J;Diaz GP;Labonne BF;Del Pilar Meza-Rodríguez M;Gelman PL
通讯作者：
Gelman PL
影响因子：
3
作者：
Earnshaw, Valerie A.;Brousseau, Natalie M.;Fox, Annie B.
通讯作者：
Fox, Annie B.
影响因子：
56.9
作者：
KARUPIAH, G;XIE, QW;MACMICKING, JD
通讯作者：
MACMICKING, JD
影响因子：
4.6
作者：
Bliddal S;Banasik K;Pedersen OB;Nissen J;Cantwell L;Schwinn M;Tulstrup M;Westergaard D;Ullum H;Brunak S;Tommerup N;Feenstra B;Geller F;Ostrowski SR;Grønbæk K;Nielsen CH;Nielsen SD;Feldt-Rasmussen U
通讯作者：
Feldt-Rasmussen U