Effects of hormone replacement therapy on glucose and lipid metabolism in peri- and postmenopausal women with a history of menstrual disorders.
Effects of hormone replacement therapy on glucose and lipid metabolism in peri- and postmenopausal women with a history of menstrual disorders.
复制标题
激素替代疗法对有月经失调史的围绝经期和绝经后妇女糖脂代谢的影响
DOI：
10.1186/s12902-021-00784-9
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发表时间：
2021-06-15
影响因子：
2.7
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Li S;Ma L;Song Y;Zheng J;Cai Y;Xu H;Chen P;Xu W;Huang Y;Qi T;Li C;Chu K;Lan Y;Xu L;Zhou J
背景
Background
Previous studies have indicated that women with a history of menstrual disorders have an increased risk of metabolic and cardiovascular diseases. This has been attributed to the high proportion of polycystic ovary syndrome (PCOS) among this group. The favorable effects of hormone replacement therapy (HRT) on serum lipid profiles and glucose homeostasis in postmenopausal women is widely accepted. Whether HRT can also show positive effects on metabolic homeostasis in menopausal women with prior menstrual disorders (a putative PCOS phenotype) has not been reported yet. The aim of the study was to compare the effects of HRT on glucose and lipid metabolism in peri- and postmenopausal women with prior menstrual disorders and controls who did not have prior menstrual disorders.
Methods
A retrospective multicenter study was conducted including 595 peri- and postmenopausal women who received HRT at four hospitals in the Zhejiang Province from May 31, 2010 to March 8, 2021. Participants were divided into the Normal menstruation group and the Menstrual disorders group according to their prior usual menstrual cycle pattern. Glucose and lipid metabolism indicators were assessed at baseline and after HRT. The results were compared between and within the groups, and data from peri- and postmenopausal women were analyzed separately.
Results
HRT significantly decreased fasting insulin and homeostasis model assessment of insulin resistance in perimenopausal users, and fasting plasma glucose levels in postmenopausal users with prior menstrual disorders, compared with baseline. Furthermore, HRT decreased low-density lipoprotein cholesterol, total cholesterol, fasting insulin, fasting plasma glucose and homeostasis model assessment of insulin resistance in both peri- and postmenopausal controls, compared with baseline. Nevertheless, no significant differences were observed in any of the glucose or lipid metabolism indicators at baseline and follow-up, as well as changes from baseline levels between menopausal women with and without prior menstrual disorders.
Conclusions
HRT shows more obvious within-group improvements in glucose and lipid metabolism in controls, but there is no significant between-group difference. Further prospective studies are required for confirmation.
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影响因子：
4.9
作者：
JENSEN, J;NILAS, L;CHRISTIANSEN, C
通讯作者：
CHRISTIANSEN, C
影响因子：
8.2
作者：
Bryzgalova, G;Gao, H;Khan, A
通讯作者：
Khan, A
影响因子：
5.9
作者：
Legro, RS;Kunselman, AR;Dunaif, A
通讯作者：
Dunaif, A
影响因子：
8.2
作者：
Margolis, KL;Bonds, DE;Howard, BV
通讯作者：
Howard, BV
影响因子：
16.2
作者：
Roumain, J;Charles, MA;Knowler, WC
通讯作者：
Knowler, WC