Time Course of Changes in Serum Oxidative Stress Markers to Predict Outcomes for Surgical Treatment of Lumbar Degenerative Disorders.
Time Course of Changes in Serum Oxidative Stress Markers to Predict Outcomes for Surgical Treatment of Lumbar Degenerative Disorders.
复制标题
DOI：
10.1155/2020/5649767
复制
发表时间：
2020
影响因子：
--
通讯作者：
Nakagawa K
中科院分区：
文献类型：
--
作者：
Takahashi H;Aoki Y;Saito J;Nakajima A;Sonobe M;Akatsu Y;Taniguchi S;Yamada M;Koyama K;Akiyama Y;Shiga Y;Inage K;Orita S;Eguchi Y;Maki S;Furuya T;Akazawa T;Koda M;Yamazaki M;Ohtori S;Nakagawa K
最近的报道表明氧化应激参与急性脊髓损伤或压迫性脊髓病的病理生物学过程。我们进行了一项观察性研究，以确定80名接受脊柱手术治疗腰椎退行性疾病相关神经症状的患者血清中氧化应激标志物的水平。术前、术后3个月、6个月、1年采集血清样本。测定血清样品中的活性氧代谢物衍生物（ROM），以测定氧化应激水平。术前神经学评估，评估患者的下肢运动无力。我们将患者样本分为两组：术后1年ROM减少组（G组）和术后1年ROM增加组（W组）。然后，我们使用视觉模拟量表和Oswestry残疾指数（ODI）评估临床结果。在80例入组患者的样本中，手术前平均ROM水平升高至388.5±92.0，表明存在中度氧化应激。术后及术后1年ROM水平逐渐下降，降至367.6±83.3 （p < 0.05）。运动无力患者的ROM值明显高于无运动无力患者（p < 0.05）。在临床结果分析中，W组术后1年ODI值显著高于G组（p < 0.05）。腰椎退行性疾病患者存在中度氧化应激，术后1年内氧化应激程度逐渐改善。临床结果表明，腰椎退行性疾病患者的神经源性氧化应激可以通过手术减轻，残留的氧化应激反映了不良的手术结果。
Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumbar degenerative disorders. Serum samples were collected before surgery and at 3 months, 6 months, and 1 year after surgery. Derivatives of reactive oxygen metabolites (ROM) in the serum samples were measured to gauge the level of oxidative stress. For preoperative neurological evaluation, patients were assessed for motor weakness in the lower extremities. We divided the patient samples into two groups: ROM decreasing at 1 year after surgery (G group) and ROM increasing at 1 year after surgery (W group). Then, we evaluated clinical outcomes using the visual analog scale and Oswestry disability index (ODI). Among the samples from the 80 enrolled patients, mean ROM levels before surgery increased to 388.5 ± 92.0, indicating the presence of moderate oxidative stress. The level of ROM gradually decreased after surgery and 1 year after surgery: the levels had significantly decreased to 367.6 ± 83.3 (p < 0.05). In patients who exhibited motor weakness, ROM values were significantly increased compared to those patients who had no motor weakness (p < 0.05). In analyses of clinical outcomes, ODI values for the W group 1 year after surgery were significantly higher than those for the G group (p < 0.05). Moderate oxidative stress was present in patients who had lumbar degenerative disorders and the degree of oxidative stress gradually improved within 1 year after surgery. The clinical results suggest that neurogenic oxidative stress can be mitigated by surgery for patients with lumbar degenerative disorders, and residual oxidative stress reflects poor surgical outcomes.
登录
查看更多内容
影响因子：
8
作者：
Vidal, Pia M.;Karadimas, Spyridon K.;Fehlings, Michael G.
通讯作者：
Fehlings, Michael G.
影响因子：
7.4
作者：
Christen, S;Finckh, B;Schmitt, B
通讯作者：
Schmitt, B
影响因子：
7.5
作者：
Carlucci, F;Tabucchi, A;Marinello, E
通讯作者：
Marinello, E
影响因子：
3.2
作者：
Faienza, Maria Felicia;Francavilla, Ruggiero;Di Bitonto, Giovanna
通讯作者：
Di Bitonto, Giovanna
影响因子：
--
作者：
Woźniak B;Woźniak A;Mila-Kierzenkowska C;Kasprzak HA
通讯作者：
Kasprzak HA