Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus.
Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus.
复制标题
大鼠过敏性鼻炎与海马体的炎症反应有关
DOI：
10.1155/2018/8750464
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发表时间：
2018
影响因子：
2.8
通讯作者：
Zhong Z
中科院分区：
文献类型：
--
作者：
Yang S;Wu J;Zhang Q;Li X;Liu D;Zeng B;Liu Z;Kang H;Zhong Z
过敏性鼻炎（AR）是个人和公共健康的主要问题，它对情绪和行为产生负面影响，导致认知缺陷，记忆力下降，学习成绩差，焦虑和抑郁。在AR的炎症过程中释放了几种细胞和分子介质，并激活了常见的神经免疫机制，涉及情感相关回路和焦虑的诱导。已经报道了下丘脑-垂体-肾上腺（HPA）轴对过敏过程的反应性，这也可能包括海马、皮质和其他脑区域的反应性。在这里，我们使用了一个优化的AR大鼠模型，以探讨这种疾病是否与海马中的炎症反应有关。通过卵清蛋白致敏在成年大鼠中建立AR，并通过特定测定测量海马中各种炎性物质的表达。实验组和各种对照组动物之间的比较显示，AR与海马中P物质、小胶质细胞表面抗原（CD 11b）、胶质细胞酸性蛋白（GFAP）、肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）的显著上调相关。因此，我们假设AR激发可能激活海马中的这些炎症介质，进而导致与AR相关的异常行为和神经功能缺损。
Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression. Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety. Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions. Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus. AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays. Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus. Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR.
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DOI：
10.1196/annals.1366.028
发表时间：
2006-01-01
期刊：
NEUROENDOCRINE AND IMMUNE CROSSTALK
影响因子：
--
作者：
Costa-Pinto, Frederico Azevedo;Basso, Alexandre Salgado;Palermo-Neto, Joao
通讯作者：
Palermo-Neto, Joao
DOI：
10.1073/pnas.0504365102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Rosenkranz, MA;Busse, WW;Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
2.6
作者：
Feng, Bohai;Jin, Haiyong;Chen, Bobei
通讯作者：
Chen, Bobei
影响因子：
5.3
作者：
Klein B;Mrowetz H;Thalhamer J;Scheiblhofer S;Weiss R;Aigner L
通讯作者：
Aigner L
影响因子：
6.1
作者：
KleinJan, A.;Willart, M.;Lambrecht, B. N.
通讯作者：
Lambrecht, B. N.