Mechanisms of D1/D2-like dopaminergic agonist, rotigotine, on lower urinary tract function in rat model of Parkinson's disease.
Mechanisms of D1/D2-like dopaminergic agonist, rotigotine, on lower urinary tract function in rat model of Parkinson's disease.
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DOI：
10.1038/s41598-022-08612-3
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发表时间：
2022-03-16
影响因子：
4.6
通讯作者：
Shinohara N
中科院分区：
文献类型：
--
作者：
Ouchi M;Kitta T;Chiba H;Higuchi M;Togo M;Abe-Takahashi Y;Shinohara N
帕金森病 (PD) 是一种由黑质致密部多巴胺能神经元缺失引起的神经退行性疾病。由于多巴胺能受体的激活从根本上参与PD的排尿反射，本研究的目的是确定单剂量罗替高汀（[−]2-(N-丙基-N-2-噻吩基乙基氨基)-5-羟基四氢化萘）对PD大鼠模型中收缩间隔（ICI）和排尿压力（VP）的影响。我们使用 27 只雌性大鼠，通过注射 6-羟基多巴胺（6-OHDA；8 μg，溶于 2 μL 含 0.3% 抗坏血酸的 0.9% 盐水）诱导 PD，并以 0.125、0.25 或 0.5 mg/kg 的剂量静脉或皮下注射罗替戈汀。在 6-OHDA 诱导的 PD 大鼠中，静脉注射 0.25 或 0.5 mg/kg 罗替高汀导致 ICI 显着低于注射媒介物后 (p<0.05)。此外，与注射媒介物的动物相比，施用罗替戈汀的动物的VP显着降低(p<0.05)。与注射载体的动物相比，皮下注射罗替戈汀（0.125、0.25 或 0.5 mg/kg）导致注射后 2 小时的 ICI 显着升高（p<<0.05）；然而，注射(+)-SCH23390盐酸盐后ICI没有变化。在帕金森病大鼠模型中经皮给予罗替高汀可以抑制膀胱过度活动症。
Parkinson’s disease (PD) is a neurodegenerative condition caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. As activation of dopaminergic receptors is fundamentally involved in the micturition reflex in PD, the objective of this study was to determine the effect of a single dose of rotigotine ([−]2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin) on intercontraction interval (ICI) and voiding pressure (VP) in a rat model of PD. We used 27 female rats, PD was induced by injecting 6-hydroxydopamine (6-OHDA; 8 μg in 2 μL of 0.9% saline containing 0.3% ascorbic acid), and rotigotine was administrated at doses of 0.125, 0.25, or 0.5 mg/kg, either intravenous or subcutaneous injection. In rats with 6-OHDA-induced PD, intravenous injection of 0.25 or 0.5 mg/kg rotigotine led to a significantly lower ICI than after vehicle injection (p < 0.05). Additionally, VP was significantly lower in animals administered rotigotine compared to those injected with vehicle (p < 0.05). Compared to vehicle-injected animals, subcutaneous administration of rotigotine (0.125, 0.25, or 0.5 mg/kg) led to a significantly higher ICI at 2 h after injection (p < 0.05); however, there was no change in ICI after injection with (+)-SCH23390 hydrochloride. Dermal administration of rotigotine in a rat model of PD could suppress an overactive bladder.
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DOI：
10.1016/j.ucl.2017.04.014
发表时间：
2017-08
期刊：
The Urologic clinics of North America
影响因子：
--
作者：
Miyazato M;Kadekawa K;Kitta T;Wada N;Shimizu N;de Groat WC;Birder LA;Kanai AJ;Saito S;Yoshimura N
通讯作者：
Yoshimura N
影响因子：
3.3
作者：
RICHFIELD, EK;PENNEY, JB;YOUNG, AB
通讯作者：
YOUNG, AB
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
影响因子：
6.6
作者：
Kitta, Takeya;Chancellor, Michael B.;Yoshimura, Naoki
通讯作者：
Yoshimura, Naoki
影响因子：
3.7
作者：
Zhou CQ;Li SS;Chen ZM;Li FQ;Lei P;Peng GG
通讯作者：
Peng GG