Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall.
Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall.
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在睡眠、清醒和记忆回忆过程中，广泛分布的波纹使人类皮层活动同步。
DOI：
10.1073/pnas.2107797119
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发表时间：
2022-07-12
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
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作者：
记忆的不同元素，或任何心理事件，都被编码在分布在大脑皮层的各个位置。一个突出的假设提出，广泛的网络是与同步的高频振荡的突发称为“涟漪”，但证据是有限的。在这里，使用人类大脑内部的记录，我们表明波纹同时发生在两个皮质半球和海马体的多个叶中，通常在睡眠和清醒期间，特别是在记忆回忆期间。纹波锁相本地单元发射和相位同步，在相距最多25 cm的位置之间几乎没有衰减，从而实现长距离集成。事实上，关联位点增加了反映细胞放电的极高频活动的相关性。因此，涟漪可能有助于在记忆和其他心理事件中将信息绑定在大脑皮层上。陈述性记忆的编码、巩固和提取需要整合广泛分布在皮层位置的编码元素。心理事件的不同组成部分被“捆绑”成统一的表征，其机制尚不清楚。“同步绑定”理论提出分布式编码区域被同步振荡绑定，从而增强通信。然而，这种振荡的证据很少。短暂的高频振荡（“波纹”）发生在海马体和皮层，有助于组织记忆回忆和巩固。在这里，使用人类颅内记录，我们报告说，这些持续时间为70 ms，90 Hz的波纹经常耦合（±500 ms内），共同发生（≥ 25 ms重叠），并且，至关重要的是，在睡眠和清醒期间，甚至在半球之间广泛分布的局灶性皮层位置之间锁相（具有一致的相位滞后）。通过多个部位的激活促进皮质涟漪共现，并且锁相随着更多皮质部位的共现而增加。所有皮质区的波纹与海马波纹共同发生，但不与它们锁相，进一步表明皮质-皮质同步是由皮质-皮质连接介导的。涟漪相位滞后在睡眠夜晚各不相同，与参与不同网络的情况一致。在清醒过程中，我们发现，当线索和反应之间的结合是必不可少的，前成功的延迟记忆回忆，海马-皮层和皮层-皮层coripples增加。纹波增加和相位调制单元发射，和coripples增加高频区域之间的相关性，这表明同步单元尖峰促进信息交换。在非常长的距离（25 cm）上保持了共存、相位同步和高频相关性，并且几乎没有衰减。海马-皮质-皮质的coripples似乎具有必要的基本属性，以支持在记忆检索过程中，也许是一般的认知同步绑定。
Different elements of a memory, or any mental event, are encoded in locations distributed across the cortex. A prominent hypothesis proposes that widespread networks are integrated with bursts of synchronized high-frequency oscillations called “ripples,” but evidence is limited. Here, using recordings inside the human brain, we show that ripples occur simultaneously in multiple lobes in both cortical hemispheres and the hippocampus, generally during sleep and waking, and especially during memory recall. Ripples phase-lock local cell firing and phase-synchronize with little decay between locations separated by up to 25 cm, enabling long-distance integration. Indeed, corippling sites have increased correlation of very-high-frequency activity which reflects cell firing. Thus, ripples may help bind information across the cortex in memory and other mental events. Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such “binding” of different components of mental events into unified representations occurs is unknown. The “binding-by-synchrony” theory proposes that distributed encoding areas are bound by synchronous oscillations enabling enhanced communication. However, evidence for such oscillations is sparse. Brief high-frequency oscillations (“ripples”) occur in the hippocampus and cortex and help organize memory recall and consolidation. Here, using intracranial recordings in humans, we report that these ∼70-ms-duration, 90-Hz ripples often couple (within ±500 ms), co-occur (≥ 25-ms overlap), and, crucially, phase-lock (have consistent phase lags) between widely distributed focal cortical locations during both sleep and waking, even between hemispheres. Cortical ripple co-occurrence is facilitated through activation across multiple sites, and phase locking increases with more cortical sites corippling. Ripples in all cortical areas co-occur with hippocampal ripples but do not phase-lock with them, further suggesting that cortico-cortical synchrony is mediated by cortico-cortical connections. Ripple phase lags vary across sleep nights, consistent with participation in different networks. During waking, we show that hippocampo-cortical and cortico-cortical coripples increase preceding successful delayed memory recall, when binding between the cue and response is essential. Ripples increase and phase-modulate unit firing, and coripples increase high-frequency correlations between areas, suggesting synchronized unit spiking facilitating information exchange. co-occurrence, phase synchrony, and high-frequency correlation are maintained with little decrement over very long distances (25 cm). Hippocampo-cortico-cortical coripples appear to possess the essential properties necessary to support binding by synchrony during memory retrieval and perhaps generally in cognition.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
DOI：
10.1126/science.aan6203
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Khodagholy D;Gelinas JN;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
5.3
作者：
Jiang, Xi;Gonzalez-Martinez, Jorge;Halgren, Eric
通讯作者：
Halgren, Eric