Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus.

Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus.
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DOI:
10.1126/science.aan6203
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发表时间:
2017-10-20
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Buzsáki G
Buzsáki G
中科院分区:
其他
文献类型:
--
作者:
Khodagholy D;Gelinas JN;Buzsáki G

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陈述性记忆的巩固需要大脑皮层-新皮层的交流。虽然实验证据支持的作用,在传递海马信息的新皮层的尖波波纹,确切的皮质目的地和生理机制,这种传输是未知的。我们使用了导电聚合物为基础的顺应性微电极阵列(NeuroGrid)记录局部场电位和神经尖峰在大鼠大脑的背侧皮层表面,结合硅探针记录在海马,以确定候选人的生理模式。顶叶、中线和前额叶,而不是初级皮质区,在睡眠期间显示局部涟漪(100至150赫兹)振荡,同时海马波纹。海马和新皮层波纹之间的耦合在学习后的睡眠过程中加强。这些研究结果表明,波纹耦合支持记忆痕迹的大脑皮层关联转移。
Consolidation of declarative memories requires hippocampal-neocortical communication. Although experimental evidence supports the role of sharp-wave ripples in transferring hippocampal information to the neocortex, the exact cortical destinations and the physiological mechanisms of such transfer are not known. We used a conducting polymer-based conformable microelectrode array (NeuroGrid) to record local field potentials and neural spiking across the dorsal cortical surface of the rat brain, combined with silicon probe recordings in the hippocampus, to identify candidate physiological patterns. Parietal, midline, and prefrontal, but not primary cortical areas, displayed localized ripple (100 to 150 hertz) oscillations during sleep, concurrent with hippocampal ripples. Coupling between hippocampal and neocortical ripples was strengthened during sleep following learning. These findings suggest that ripple-ripple coupling supports hippocampal-association cortical transfer of memory traces.
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