Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests.
Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests.
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透明质酸可改善老年骨关节炎膝关节的疼痛、身体功能和平衡：一项使用临床测试的 6 个月随访研究。
DOI：
10.1016/j.joca.2006.01.010
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发表时间：
2006
影响因子：
7
通讯作者：
Yu
中科院分区：
文献类型：
--
作者：
Shu;Chien;Chiao;Pei;Jue;Shin;Yi;Ya;Chien;Yu
目的探讨关节内透明质酸（HA） （Artzal, Seikagaku Corp., Japan）在老年单侧膝骨关节炎（OA）患者中的作用。方法本研究是一项前瞻性、观察盲研究，随访6个月，在一所大学附属三级医疗中心门诊康复科进行。68例患者，年龄65岁或以上，有单侧膝关节OA症状和影像学证据至少6个月。患者每周5次在有症状的膝盖关节内注射Artzal。56名参与者完成了这项研究。选择50名年龄、体重和性别匹配的健康个体作为对照。在注射前及每次随访时评估OA组的视觉模拟量表（VAS）、Lequesne指数及单腿站立测试（SLS）、功能到达测试（FRT）、定时“上-走”测试（TUG）和Berg平衡量表（BBS）等4项平衡测试。对健康参与者进行了四次平衡测试以进行数据比较。结果OA组VAS评分、Lequesne评分和四项平衡测试评分均明显低于对照组（P<0.001）。在第五次注射后的1周、1、3和6个月，与注射前的基线相比，所有结局指标均有显著改善。4例（7.1%）患者报告了局部不良事件。结论：老年膝关节OA患者每周注射5次阿尔扎尔后，疼痛、身体功能和平衡测试均有显著改善。效果在1周内迅速起效，并可持续6个月。
OBJECTIVETo investigate the effects of intraarticular hyaluronic acid (HA) (Artzal, Seikagaku Corp., Japan) in geriatric participants with unilateral knee osteoarthritis (OA).METHODThis was a prospective, observer-blind study with 6 months follow-up done in the setting of an outpatient rehabilitation department in a university-affiliated tertiary care medical center. Sixty-eight patients, aged 65 years or above, with symptoms and radiographic evidence of unilateral knee OA for at least 6 months were recruited. Patients received five weekly intraarticular injections of Artzal into symptomatic knees. Fifty-six participants completed the study. Fifty age-, body mass- and gender-matched healthy individuals were selected as control. Visual analog scale (VAS), Lequesne index and four balance tests including single-leg stance test (SLS), function reach test (FRT), timed “Up-and-Go” test (TUG) and Berg balance scale (BBS) were assessed before injection and at each follow-up visit in the OA group. Four balance tests were obtained on healthy participants for data comparison.RESULTSBefore Artzal injections, the OA group showed significantly worse VAS, Lequesne index and four balance tests scores than did the control group (P<0.001). Significant improvement in all outcome measures were noted at 1 week, 1, 3 and 6 months post the fifth injection compared with baseline before injection. Local adverse events were reported in four patients (7.1%).CONCLUSIONSignificant improvement in pain, physical function and balance tests was demonstrated after five weekly Artzal injections in geriatric patients with knee OA. The effect had rapid onset at 1 week and may last for 6 months.
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影响因子：
--
作者：
Pai, YC;Rymer, WZ;Sharma, L
通讯作者：
Sharma, L
DOI：
--
发表时间：
1991-04
期刊：
The Journal of rheumatology
影响因子：
--
作者：
M. Davis;W. Ettinger;J. Neuhaus;K. P. Mallon
通讯作者：
M. Davis;W. Ettinger;J. Neuhaus;K. P. Mallon
影响因子：
12.7
作者：
GUCCIONE, AA;FELSON, DT;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
3.2
作者：
Shumway-Cook, A;Brauer, S;Woollacott, M
通讯作者：
Woollacott, M
影响因子：
168.9
作者：
HUSKISSON, EC
通讯作者：
HUSKISSON, EC