Controlled Bioactive Delivery Using Degradable Electroactive Polymers.
Controlled Bioactive Delivery Using Degradable Electroactive Polymers.
复制标题
使用可降解电活性聚合物的受控生物活性递送。
DOI：
10.1021/acs.biomac.2c00516
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发表时间：
2022-07-11
影响因子：
6.2
通讯作者：
Hardy, John G.
中科院分区：
文献类型：
--
作者：
Ashton, Mark D.;Cooper, Patricia A.;Municoy, Sofia;Desimone, Martin F.;Cheneler, David;Shnyder, Steven D.;Hardy, John G.
能够精确控制农用化学品/生物制品/药物/香料释放的生物材料在农业科学/医疗保健行业具有重要市场。在此，我们报道了可降解电活性聚合物的研发及其在临床相关药物（抗炎药磷酸地塞米松，DMP）控制释放方面的应用。制备了由聚己内酯（PCL）嵌段和天然存在的电活性吡咯低聚物（例如胆红素、胆绿素和血红素）组成的电活性共聚物，并通过溶液加工制成薄膜（可选择掺杂DMP）。计算机模拟/体外/体内研究相结合，证明了这些聚合物的细胞相容性。观察到在施加电刺激时，DMP的释放量相对于体外无刺激样品的被动释放量提高了约10 - 30%。这种刺激响应性生物材料有可能集成到能够为技术/医疗应用输送多种分子的装置中。
Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10–30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.
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药物输送系统的临床和商业影响概述。
DOI：
10.1016/j.jconrel.2014.03.053
发表时间：
2014-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Anselmo AC;Mitragotri S
通讯作者：
Mitragotri S
影响因子：
3.2
作者：
Ashton, Mark D.;Appen, Isabel C.;Hardy, John G.
通讯作者：
Hardy, John G.
影响因子：
3.6
作者：
Bayer, Carolyn L.;Trenchard, Isis J.;Peppas, Nicholas A.
通讯作者：
Peppas, Nicholas A.
影响因子：
4
作者：
Chapman, Christopher A. R.;Cuttaz, Estelle A.;Green, Rylie A.
通讯作者：
Green, Rylie A.
影响因子：
6.2
作者：
Gianti, Eleonora;Percec, Simona
通讯作者：
Percec, Simona