Circulating MicroRNAs predict glycemic improvement and response to a behavioral intervention.
Circulating MicroRNAs predict glycemic improvement and response to a behavioral intervention.
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DOI：
10.1186/s40364-021-00317-5
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发表时间：
2021-08-23
影响因子：
11.1
通讯作者：
Aouizerat BE
中科院分区：
文献类型：
--
作者：
Flowers E;Allen IE;Kanaya AM;Aouizerat BE
微小RNA可能是2型糖尿病风险的重要调节因子。这项纵向观察性研究的目的是评估循环microRNA是否预测空腹血糖的改善，这是2型糖尿病的主要危险因素，超过12个月。该研究包括来自先前完成的试验的参与者（n = 82），该试验测试了恢复性瑜伽对糖尿病前期患者的影响。使用流式细胞术miRNA测定来测量循环microRNA。使用线性模型来确定总体和干预组的microRNA预测因子的最佳集合。microRNA亚组是12个月后最终空腹血糖（R2 = 0.754，p <0.001）和12个月内空腹血糖变化（R2 = 0.731，p <0.001）的显著预测因子。三种microRNA（let-7c，miR-363，miR-374b）仅在对照组中具有显著性，但干预组之间没有显著的相互作用。循环microRNA是糖尿病前期个体空腹血糖的重要预测因子。在已鉴定的microRNA中，有几种以前与2型糖尿病的风险有关。这是第一个使用纵向设计来评估microRNA是否预测空腹血糖随时间变化的研究之一。对这些模型中microRNA功能的进一步探索可能会为2型糖尿病的复杂病因学和对行为风险降低干预的反应提供新的见解。本研究是对先前已完成的临床试验的次要分析，该临床试验于2009年12月3日在www.example.com（NCT 01024816）上注册。在线版本包含补充材料，可通过10.1186/s40364 - 021 - 00317 - 5获得。
MicroRNAs may be important regulators of risk for type 2 diabetes. The purpose of this longitudinal observational study was to assess whether circulating microRNAs predicted improvements in fasting blood glucose, a major risk factor for type 2 diabetes, over 12 months. The study included participants (n = 82) from a previously completed trial that tested the effect of restorative yoga on individuals with prediabetes. Circulating microRNAs were measured using a flow cytometry miRNA assay. Linear models were used to determine the optimal sets of microRNA predictors overall and by intervention group. Subsets of microRNAs were significant predictors of final fasting blood glucose after 12-months (R2 = 0.754, p < 0.001) and changes in fasting blood glucose over 12-months (R2 = 0.731, p < 0.001). Three microRNAs (let-7c, miR-363, miR-374b) were significant for the control group only, however there was no significant interaction by intervention group. Circulating microRNAs are significant predictors of fasting blood glucose in individuals with prediabetes. Among the identified microRNAs, several have previously been associated with risk for type 2 diabetes. This is one of the first studies to use a longitudinal design to assess whether microRNAs predict changes in fasting blood glucose over time. Further exploration of the function of the microRNAs included in these models may provide new insights about the complex etiology of type 2 diabetes and responses to behavioral risk reduction interventions. This study was a secondary analysis of a previously completed clinical trial that is registered at clinicaltrials.gov (NCT01024816) on December 3, 2009. The online version contains supplementary material available at 10.1186/s40364-021-00317-5.
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影响因子：
11.1
作者：
Flowers E;Gadgil M;Aouizerat BE;Kanaya AM
通讯作者：
Kanaya AM
影响因子：
2.4
作者：
Gao, Chao;Qian, Hengbo;Zhang, Hua
通讯作者：
Zhang, Hua
miRNA-93抑制GLUT4，并在多囊卵巢综合征患者和具有胰岛素抵抗的女性的脂肪组织中过表达。
影响因子：
7.7
作者：
Chen YH;Heneidi S;Lee JM;Layman LC;Stepp DW;Gamboa GM;Chen BS;Chazenbalk G;Azziz R
通讯作者：
Azziz R
影响因子：
2.2
作者：
Flowers, E.;Kanaya, A. M.;Aouizerat, B. E.
通讯作者：
Aouizerat, B. E.
影响因子：
--
作者：
Guo L;Yang S;Zhao Y;Zhang H;Wu Q;Chen F
通讯作者：
Chen F