Antibiotic alternatives: the substitution of antibiotics in animal husbandry?
Antibiotic alternatives: the substitution of antibiotics in animal husbandry?
复制标题
抗生素替代品：畜牧业中抗生素的替代品？
DOI：
10.3389/fmicb.2014.00217
复制
发表时间：
2014
影响因子：
5.2
通讯作者：
Yuan Z
中科院分区：
文献类型：
--
作者：
Cheng G;Hao H;Xie S;Wang X;Dai M;Huang L;Yuan Z
在现代畜牧业中，为预防动物疾病和提高生产性能，在食用动物饲料中使用亚治疗剂量的抗生素是几十年来的普遍做法。与此同时，由于抗生素的不合理使用和较少新颖抗生素的出现，对抗生素耐药细菌日益增加的担忧促使人们努力开发所谓的抗生素替代品。这些替代品是否真的可以取代抗生素仍然是一个有争议的问题。本文综述了抗生素替代品的最新发展和前景。本文对免疫调节剂、噬菌体及其溶酶、抗菌肽、前、前和合成制剂、植物提取物、靶向致病性抑制剂（细菌群体感应、生物膜和毒力）和摄食酶的作用机制、应用和前景进行了深入讨论。最后，深入分析了抗生素替代品的可行性。在可预见的未来，很难断定这些替代品可能会取代兽药中的抗生素。目前，谨慎使用抗生素和建立科学的监测系统是限制抗生素滥用不良影响，确保动物源性食品和环境安全的最好和最快的方法。
It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-animal feeds to prevent animals from diseases and to improve production performance in modern animal husbandry. In the meantime, concerns over the increasing emergence of antibiotic-resistant bacteria due to the unreasonable use of antibiotics and an appearance of less novelty antibiotics have prompted efforts to develop so-called alternatives to antibiotics. Whether or not the alternatives could really replace antibiotics remains a controversial issue. This review summarizes recent development and perspectives of alternatives to antibiotics. The mechanism of actions, applications, and prospectives of the alternatives such as immunity modulating agents, bacteriophages and their lysins, antimicrobial peptides, pro-, pre-, and synbiotics, plant extracts, inhibitors targeting pathogenicity (bacterial quorum sensing, biofilm, and virulence), and feeding enzymes are thoroughly discussed. Lastly, the feasibility of alternatives to antibiotics is deeply analyzed. It is hard to conclude that the alternatives might substitute antibiotics in veterinary medicine in the foreseeable future. At the present time, prudent use of antibiotics and the establishment of scientific monitoring systems are the best and fastest way to limit the adverse effects of the abuse of antibiotics and to ensure the safety of animal-derived food and environment.
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DOI：
10.1016/0167-4838(92)90073-m
发表时间：
1992-09-04
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CALDENTEY, J;BAMFORD, DH
通讯作者：
BAMFORD, DH
影响因子：
3.1
作者：
Bjarnsholt, Thomas;Givskov, Michael
通讯作者：
Givskov, Michael
影响因子：
2.6
作者：
BERCHIERI, A;LOVELL, MA;BARROW, PA
通讯作者：
BARROW, PA
影响因子：
5.2
作者：
Alipour, Misagh;Suntres, Zacharias E.;Omri, Abdelwahab
通讯作者：
Omri, Abdelwahab
影响因子：
2.7
作者：
Apajalahti, J;Kettunen, A;Graham, H
通讯作者：
Graham, H