The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register.
The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register.
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抗菌柠檬硫化肽抗体在预测炎症性多关节炎中放射学损伤严重程度时的性能：诺福克关节炎登记册的结果。
DOI：
10.1002/art.22868
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发表时间：
2007-09
影响因子：
--
通讯作者：
Barton, A.
中科院分区：
文献类型：
--
作者：
Bukhari, M.;Thomson, W.;Naseem, H.;Bunn, D.;Silman, A.;Symmons, D.;Barton, A.
抗环瓜氨酸肽（抗 CCP）抗体比类风湿因子（RF）更能预测类风湿关节炎的严重程度。它们在预测未经选择的新发炎症性多关节炎 (IP) 患者预后方面的作用尚未得到检验。本研究的目的是检查基线 RF 和抗 CCP 抗体在确定患者出现糜烂的可能性或预测未来放射学损伤方面的作用，并确定抗 CCP 抗体或 RF 是否足够稳健，可在临床上指导早期 IP 的治疗决策。患者是从诺福克关节炎登记处招募的。拟合逻辑回归模型来测试抗 CCP 抗体和 RF 预测侵蚀的能力。研究了进一步的模型来检查抗 CCP 抗体在按 RF 状态分层的患者中的作用。基线时抗 CCP 抗体的存在与普遍的糜烂（比值比 [OR] 2.53 [95% 置信区间 (95% CI) 1.48–4.30]）和 5 年时出现糜烂（OR 10.2 [95% CI 6.2–16.9]）密切相关。这些 OR 高于 RF（分别为 OR 1.63 [95% CI 0.94–2.82] 和 OR 3.4 [95% CI 2.2–5.2]）。 RF-亚组中预测普遍侵蚀和 5 年侵蚀的似然比 (LR) 最高（LR 分别为 2.2 和 5.8）。然而，27% 的抗 CCP 患者在 5 年内出现了糜烂。尽管抗 CCP 抗体与糜烂的存在、发展和程度密切相关，但单独使用抗 CCP 抗体并不足以准确地衡量临床治疗决策的依据。对于 RF 阴性患者，了解抗 CCP 抗体状态的信息最为丰富。
Anti–cyclic citrullinated peptide (anti-CCP) antibodies are a stronger predictor of the severity of rheumatoid arthritis than is rheumatoid factor (RF). Their role in predicting outcome in unselected patients with new-onset inflammatory polyarthritis (IP) has not been examined. The aims of this study were to examine the role of baseline RF and anti-CCP antibodies in determining the likelihood of patients having erosions at presentation or in predicting future radiologic damage, and to determine whether anti-CCP antibodies or RF is sufficiently robust to be clinically useful in guiding treatment decisions in early IP. Patients were recruited from the Norfolk Arthritis Register. Logistic regression models were fitted to test the ability of anti-CCP antibodies and RF to predict erosions. Further models were investigated to examine the role of anti-CCP antibodies in patients stratified by RF status. The presence of anti-CCP antibodies at baseline was strongly associated with both prevalent erosions (odds ratio [OR] 2.53 [95% confidence interval (95% CI) 1.48–4.30]) and developing erosions at 5 years (OR 10.2 [95% CI 6.2–16.9]). These ORs were higher than those for RF (OR 1.63 [95% CI 0.94–2.82] and OR 3.4 [95% CI 2.2–5.2], respectively). The likelihood ratio (LR) for the prediction of prevalent erosions and erosions at 5 years was highest in the RF−subgroup (LR 2.2 and 5.8, respectively). However, 27% of anti-CCP−patients had developed erosions by 5 years. Despite their strong association with the presence, development, and extent of erosions, anti-CCP antibodies alone are not a sufficiently accurate measure upon which to base clinical treatment decisions. Knowledge of anti-CCP antibody status is most informative in RF−negative patients.
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影响因子：
4.9
作者：
van der Helm-van Mil AH;Verpoort KN;Breedveld FC;Toes RE;Huizinga TW
通讯作者：
Huizinga TW
循环柠檬硫化肽自身抗体的序列测定预测了前瞻性类风湿关节炎患者的五年放射学结果。
影响因子：
4.9
作者：
Meyer, Olivier;Nicaise-Roland, Pascale;Santos, Marie Dos;Labarre, Colette;Dougados, Maxime;Goupille, Philippe;Cantagrel, Alain;Sibilia, Jean;Combe, Bernard
通讯作者：
Combe, Bernard
影响因子：
27.4
作者：
Berglin, E;Johansson, T;Rantapää-Dahlqvist, S
通讯作者：
Rantapää-Dahlqvist, S
抗偶然柠檬硫化肽抗体和类风湿因子与类风湿关节炎的放射学严重程度的独立关联。
影响因子：
4.9
作者：
Mewar, Devesh;Coote, Annabel;Moore, David J;Marinou, Ioanna;Keyworth, Jodie;Dickson, Marion C;Montgomery, Doug S;Binks, Michael H;Wilson, Anthony G
通讯作者：
Wilson, Anthony G
影响因子：
2.1
作者：
MARCH, RE;KIRWAN, JR;HOLBOROW, EJ
通讯作者：
HOLBOROW, EJ