Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature.
Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature.
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DOI：
10.1155/2017/3494867
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发表时间：
2017
影响因子：
--
通讯作者：
Mertens PR
中科院分区：
文献类型：
--
作者：
Liakopoulos V;Roumeliotis S;Gorny X;Eleftheriadis T;Mertens PR
与一般人群和透析前慢性肾病患者相比，腹膜透析（PD）患者表现出过度氧化应激（OS），主要是由于PD溶液的组成（高葡萄糖含量、低pH值、渗透压升高、乳酸盐浓度增加和葡萄糖降解产物）。然而，与血液透析（HD）相比，PD可以被认为是一种生物相容性更好的透析形式，因为几项研究表明，后者会导致氧化产物的过度积累和抗氧化剂的损失。PD患者的OS与慢性炎症、动脉粥样硬化形成、腹膜纤维化和残余肾功能丧失密切相关。虽然外源性补充抗氧化剂，如维生素E和C，N-乙酰半胱氨酸和类胡萝卜素，在某些情况下，显示出潜在的有益效果，在PD患者，相关的建议尚未在日常临床实践中采用。
Peritoneal dialysis (PD) patients manifest excessive oxidative stress (OS) compared to the general population and predialysis chronic kidney disease patients, mainly due to the composition of the PD solution (high-glucose content, low pH, elevated osmolality, increased lactate concentration and glucose degradation products). However, PD could be considered a more biocompatible form of dialysis compared to hemodialysis (HD), since several studies showed that the latter results in an excess accumulation of oxidative products and loss of antioxidants. OS in PD is tightly linked with chronic inflammation, atherogenesis, peritoneal fibrosis, and loss of residual renal function. Although exogenous supplementation of antioxidants, such as vitamins E and C, N-acetylcysteine, and carotenoids, in some cases showed potential beneficial effects in PD patients, relevant recommendations have not been yet adopted in everyday clinical practice.
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