Baculovirus-mediated gene delivery and RNAi applications.
Baculovirus-mediated gene delivery and RNAi applications.
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DOI:
10.3390/v7042099
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发表时间:
2015-04-22
期刊:
影响因子:
--
通讯作者:
Ylä-Herttulala S
中科院分区:
文献类型:
--
作者:
Makkonen KE;Airenne K;Ylä-Herttulala S
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications including protein production and gene transfer. Multiple in vitro and in vivo studies exist and support their use as gene delivery vehicles in vertebrate cells. Recently, baculoviruses have also demonstrated high potential in RNAi applications in which several advantages of the virus make it a promising tool for RNA gene transfer with high safety and wide tropism.
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