Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy.
Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy.
复制标题
在分析治疗计划系统的碳离子放射疗法中计算剂量平均线性能量转移。
DOI：
10.1002/acm2.13866
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发表时间：
2023-02
影响因子：
2.1
通讯作者：
Zhao, Jingfang
中科院分区：
文献类型：
--
作者：
Wang, Weiwei;Li, Ping;Shahnazi, Kambiz;Wu, Xiaodong;Zhao, Jingfang
关键词：
令人信服的证据表明，碳离子放射治疗（CIRT）的相对生物学有效性（RBE）与剂量平均线性能量转移（LETd）之间存在关联。然而，缺乏在商业上可获得的治疗计划系统（TPS）中计算LETd的能力。本研究旨在开发一种计算CIRT计划的LETd的方法，该方法可以在RayStation（V10B，Raysearch，瑞典）中稳健地进行。计算使用RayStation中的碎片光谱进行CIRT治疗计划。剂量加权平均程序得到微剂量动力学模型（MKM）的支持。用于计算RBE加权剂量的基于MKM的笔形射束剂量引擎（PBA，v4.2）被重新制定为LET加权计算引擎。然后配置一个单独的模块，根据计划的吸收剂量和相关的碎片光谱逆计算LETd。在本研究中，LETd模块中的离子和能量特定LET表与Syngo TPS（V13 C，Siemens，德国）基线数据解码的值进一步匹配。计算了几种单能和调制光束的LETd分布，并与来自Syngo TPS和已发表数据的值进行了验证。新方法和传统方法之间的单能光束的LETds在入口和布拉格峰区域的差异在3%以内。然而，在远端区域观察到更大的差异。调制光束的结果与已发表的文献中的工作符合得很好。本文介绍的方法重新制定了RayStation TPS中的MKM剂量引擎，以逆向计算LETds。证明了耐用性和准确度。
Compelling evidence shows the association between the relative biological effectiveness (RBE) of carbon‐ion radiotherapy (CIRT) and the dose averaged linear energy transfer (LETd). However, the ability to calculate the LETd in commercially available treatment planning systems (TPS) is lacking. This study aims to develop a method of calculating the LETd of CIRT plans that could be robustly carried out in RayStation (V10B, Raysearch, Sweden). The calculation used the fragment spectra in RayStation for the CIRT treatment planning. The dose‐weighted averaging procedure was supported by the microdosimetric kinetic model (MKM). The MKM‐based pencil beam dose engine (PBA, v4.2) for calculating RBE‐weighted doses was reformulated to become a LET‐weighted calculating engine. A separate module was then configured to inversely calculate the LETd from the absorbed dose of a plan and the associated fragment spectra. In this study, the ion and energy‐specific LET table in the LETd module was further matched with the values decoded from the baseline data of the Syngo TPS (V13C, Siemens, Germany). The LETd distributions of several monoenergetic and modulated beams were calculated and validated against the values derived from the Syngo TPS and the published data. The differences in LETds of the monoenergetic beams between the new method and the traditional method were within 3% in the entrance and Bragg‐peak regions. However, a larger difference was observed in the distal region. The results of the modulated beams were in good agreement with the works from the published literature. The method presented herein reformulates the MKM dose engine in the RayStation TPS to inversely calculate LETds. The robustness and accuracy were demonstrated.
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