Functional resting-state networks are differentially affected in schizophrenia.
Functional resting-state networks are differentially affected in schizophrenia.
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DOI：
10.1016/j.schres.2011.03.010
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发表时间：
2011-08
影响因子：
4.5
通讯作者：
Heckers, Stephan
中科院分区：
文献类型：
--
作者：
Woodward, Neil D.;Rogers, Baxter;Heckers, Stephan
神经生物学理论认为，精神分裂症与大脑区域之间的连接障碍有关。静息态功能磁共振成像是检查功能连接的有力工具，并揭示了几个典型的大脑网络，包括默认模式，背侧注意，执行控制和显着性网络。本研究的目的是检查这些网络在精神分裂症的变化。42名精神分裂症患者和61名健康受试者完成了RS-fMRI扫描。种子为基础的区域的利益相关性分析被用来确定默认模式，背侧注意，执行控制，和显着性网络。与健康受试者相比，精神分裂症患者的后扣带皮层（默认模式的关键枢纽）与左下回、左额中回和左颞中回之间的连接性更强。有趣的是，这些区域与健康对照受试者的执行控制网络联系更紧密。与默认模式相比，患者在执行控制和背侧注意网络中表现出较少的连通性。在显着性网络中没有观察到差异。结果表明，休息状态网络在精神分裂症中受到不同的影响。这些改变的特征是前额叶皮层和颞叶中默认模式和执行控制网络之间的隔离减少，以及背侧注意力和执行控制网络之间的连接减少。这些变化表明精神分裂症患者的功能特化过程发生了改变。需要进一步的工作来确定这些改变是否与白色物质连接障碍、神经发育异常和精神分裂症的遗传风险有关。
Neurobiological theories posit that schizophrenia relates to disturbances in connectivity between brain regions. Resting-state functional magnetic resonance imaging is a powerful tool for examining functional connectivity and has revealed several canonical brain networks, including the default mode, dorsal attention, executive control, and salience networks. The purpose of this study was to examine changes in these networks in schizophrenia. 42 patients with schizophrenia and 61 healthy subjects completed a RS-fMRI scanning session. Seed-based region-of-interest correlation analysis was used to identify the default mode, dorsal attention, executive control, and salience networks. Compared to healthy subjects, individuals with schizophrenia demonstrated greater connectivity between the posterior cingulate cortex, a key hub of the default mode, and the left inferior gyrus, left middle frontal gyrus, and left middle temporal gyrus. Interestingly, these regions were more strongly connected to the executive control network in healthy control subjects. In contrast to the default mode, patients demonstrated less connectivity in the executive control and dorsal attention networks. No differences were observed in the salience network. The results indicate that resting-state networks are differentially affected in schizophrenia. The alterations are characterized by reduced segregation between the default mode and executive control networks in the prefrontal cortex and temporal lobe, and reduced connectivity in the dorsal attention and executive control networks. The changes suggest that the process of functional specialization is altered in schizophrenia. Further work is needed to determine if the alterations are related to disturbances in white matter connectivity, neurodevelopmental abnormalities, and genetic risk for schizophrenia.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
--
作者：
Minzenberg, Michael J.;Laird, Angela R.;Thelen, Sarah;Carter, Cameron S.;Glahn, David C.
通讯作者：
Glahn, David C.
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影响因子：
17.7
作者：
Lui, Su;Deng, Wei;Gong, Qiyong
通讯作者：
Gong, Qiyong
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
6.7
作者：
Friston, KJ
通讯作者：
Friston, KJ