Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells.
Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells.
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DOI：
10.1039/c5sc03540f
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发表时间：
2016-02-01
期刊：
影响因子：
8.4
通讯作者：
Ishibashi M
中科院分区：
文献类型：
--
作者：
Arai MA;Ishikawa N;Tanaka M;Uemura K;Sugimitsu N;Suganami A;Tamura Y;Koyano T;Kowithayakorn T;Ishibashi M
Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells was isolated by using Hes1-immobilized beads. The Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells is described. Six natural products, including one new natural product, which bind to Hes1 were rapidly isolated by a developed “target protein oriented natural products isolation” (TPO-NAPI) method using Hes1-immobilized beads. Of the six compounds, 2 inhibited Hes1 dimer formation at both the protein- and cellular level. Neural stem cells treated with 2 differentiated to neurons with longer neurites than cells treated with varproic acid or retinoic acid. Moreover, 2 exhibited specificity for neurons. This promotion of differentiation was supported by an increase in the mRNA expression of the proneural genes, Mash1 and Ngn2, which were inhibited by Hes1.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
DOI：
10.1111/j.1365-2443.2010.01413.x
发表时间：
2010-06
期刊：
Genes to cells : devoted to molecular & cellular mechanisms
影响因子：
--
作者：
Kobayashi T;Kageyama R
通讯作者：
Kageyama R
影响因子：
4.6
作者：
Kageyama, Ryoichiro;Ohtsuka, Toshiyuki;Kobayashi, Taeko
通讯作者：
Kobayashi, Taeko
影响因子：
2.5
作者：
Jin, GH;Tan, XF;Xu, HJ
通讯作者：
Xu, HJ
影响因子：
3.3
作者：
KOJIRI, K;NAKAJIMA, S;SUDA, H
通讯作者：
SUDA, H