In vivo multisite oximetry using EPR-NMR coimaging.
In vivo multisite oximetry using EPR-NMR coimaging.
复制标题
DOI：
10.1016/j.jmr.2010.08.011
复制
发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Zweier JL
中科院分区：
文献类型：
--
作者：
Ahmad R;Caia G;Potter LC;Petryakov S;Kuppusamy P;Zweier JL
采用电子顺磁共振（EPR）成像和核磁共振成像的共成像技术用于快速体内血氧测定，同时在小鼠的多个器官进行。最近开发的混合EPR-NMR共成像仪器用于EPR和NMR测量。氧敏感颗粒EPR探针被植入小的局部口袋，称为位点，跨越活小鼠的多个区域。三维MRI用于生成解剖可视化，提供植入部位的精确位置。然后根据EPR测量估计每个站点的pO2值。为了考虑携带有损样本的大型谐振器内的射频相位不均匀性，提出了现有EPR数据模型的推广。利用已知的谱线形状、稀疏分布和已知的位点位置，比传统的光谱空间成像减少了EPR数据收集的一个数量级以上，提高了体内EPR血氧测定在临床相关模型中的可行性。
Coimaging employing electron paramagnetic resonance (EPR) imaging and MRI is used for rapid in vivo oximetry conducted simultaneously across multiple organs of a mouse. A recently developed hybrid EPR-NMR coimaging instrument is used for both EPR and NMR measurements. Oxygen sensitive particulate EPR probe is implanted in small localized pockets, called sites, across multiple regions of a live mouse. Three dimensional MRI is used to generate anatomic visualization, providing precise locations of implant sites. The pO2 values, one for every site, are then estimated from EPR measurements. To account for radio frequency (RF) phase inhomogeneities inside a large resonator carrying a lossy sample, a generalization of an existing EPR data model is proposed. Utilization of known spectral lineshape, sparse distribution, and known site locations reduce the EPR data collection by more than an order of magnitude over a conventional spectral-spatial imaging, enhancing the feasibility of in vivo EPR oximetry for clinically relevant models.
登录
查看更多内容
影响因子：
11.5
作者：
Matsumoto, K;Hyodo, F;Krishna, MC
通讯作者：
Krishna, MC
影响因子：
3.4
作者：
Halpern, HJ;Yu, C;Teicher, BA
通讯作者：
Teicher, BA
影响因子：
2.2
作者：
Som, Subhojit;Potter, Lee C.;Kuppusamy, Periannan
通讯作者：
Kuppusamy, Periannan
影响因子：
4.4
作者：
FREED, JH;LENIART, DS;HYDE, JS
通讯作者：
HYDE, JS
影响因子：
2.2
作者：
Joshi, JP;Ballard, JR;Eaton, GR
通讯作者：
Eaton, GR