Mechanisms of growth and homeostasis in the Drosophila wing.
Mechanisms of growth and homeostasis in the Drosophila wing.
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DOI:
10.1146/annurev.cellbio.24.110707.175242
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发表时间:
2009
影响因子:
11.3
通讯作者:
Johnston LA
中科院分区:
文献类型:
--
作者:
Neto-Silva RM;Wells BS;Johnston LA
Animal shape and size is controlled with amazing precision during development. External factors such as nutrient availability and crowding can alter overall animal size, but individual body parts scale reproducibly to match the body even with challenges from a changing environment. How is such precision achieved? Here, we review selected research from the last few years in Drosophila - arguably the premier genetic model for study of animal growth - that sheds light on how body and tissue size are regulated by forces intrinsic to individual organs. We focus on two topics currently under intense study: the influence of pattern regulators on organ and tissue growth, and the role of local competitive interactions between cells in tissue homeostasis and final size.
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