Mechanisms of growth and homeostasis in the Drosophila wing.

Mechanisms of growth and homeostasis in the Drosophila wing.
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DOI:
10.1146/annurev.cellbio.24.110707.175242
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发表时间:
2009
影响因子:
11.3
通讯作者:
Johnston LA
Johnston LA
中科院分区:
生物学1区
文献类型:
--
作者:
Neto-Silva RM;Wells BS;Johnston LA

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在发育过程中,动物的形状和大小得到了惊人的精确控制。营养供应和拥挤等外部因素可能会改变动物的整体体型,但即使面临环境变化的挑战,各个身体部位也会重复缩放以匹配身体。这样的精度是如何实现的呢?在这里,我们回顾了过去几年果蝇的精选研究——可以说是动物生长研究的首要遗传模型——这些研究揭示了个体器官固有的力量如何调节身体和组织的大小。我们重点关注目前正在深入研究的两个主题:模式调节因子对器官和组织生长的影响,以及细胞之间局部竞争性相互作用在组织稳态和最终大小中的作用。
Animal shape and size is controlled with amazing precision during development. External factors such as nutrient availability and crowding can alter overall animal size, but individual body parts scale reproducibly to match the body even with challenges from a changing environment. How is such precision achieved? Here, we review selected research from the last few years in Drosophila - arguably the premier genetic model for study of animal growth - that sheds light on how body and tissue size are regulated by forces intrinsic to individual organs. We focus on two topics currently under intense study: the influence of pattern regulators on organ and tissue growth, and the role of local competitive interactions between cells in tissue homeostasis and final size.
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