Enhanced development of azoxymethane-induced colonic preneoplastic lesions in hypertensive rats.
Enhanced development of azoxymethane-induced colonic preneoplastic lesions in hypertensive rats.
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DOI：
10.3390/ijms140714700
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发表时间：
2013-07-15
影响因子：
5.6
通讯作者：
Moriwaki H
中科院分区：
文献类型：
--
作者：
Kochi T;Shimizu M;Ohno T;Baba A;Sumi T;Kubota M;Shirakami Y;Tsurumi H;Tanaka T;Moriwaki H
代谢综合征与结直肠癌风险增加有关。本研究使用 SHRSP/Izm (SHRSP) 非糖尿病/高血压大鼠和 SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) 糖尿病/高血压大鼠，研究了高血压（代谢综合征的一个组成部分）对氧化偶氮甲烷 (AOM) 诱导的结直肠癌发生的影响。雄性 6 周龄 SHRSP、SHRSP-ZF 和对照非糖尿病/血压正常 Wister Kenya/Izm (WKY) 大鼠每周 2 次腹膜内注射 AOM（20 mg/kg 体重）。最后一次注射 AOM 两周后，与对照 WKY 大鼠相比，SHRSP 和 SHRSP-ZF 大鼠出现高血压。 SHRSP 和 SHRSP-ZF 大鼠的血清血管紧张素-II（肾素-血管紧张素系统的活性产物）水平均升高，但只有 SHRSP-ZF 大鼠出现胰岛素抵抗、血脂异常和高瘦素血症，并表现出脂肪组织增加。与 WKY 正常血压大鼠相比，SHRSP 和 SHRSP-ZF 高血压大鼠中 AOM 诱导的结肠癌前病变和异常隐窝病灶的发展显着加速。此外，在 SHRSP 和 SHRSP-ZF 大鼠的结肠粘膜和系统中观察到氧化应激的诱导和炎症的加剧。我们的研究结果表明，高血压通过诱导氧化应激和慢性炎症在结直肠癌发生的早期阶段发挥作用，这可能与肾素-血管紧张素系统的激活有关。
Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system.
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影响因子：
4.8
作者：
Massiéra, F;Bloch-Faure, M;Teboul, M
通讯作者：
Teboul, M
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
影响因子：
168.9
作者：
Lever, AF;Hole, DJ;Robertson, JWK
通讯作者：
Robertson, JWK
DOI：
10.1111/j.1440-1681.2004.03962.x
发表时间：
2004-01-01
影响因子：
2.9
作者：
Hiraoka-Yamamoto, J;Nara, Y;Ikeda, K
通讯作者：
Ikeda, K
DOI：
10.1016/j.bbrc.2011.05.115
发表时间：
2011-06-24
影响因子：
3.1
作者：
Kubota, Masaya;Shimizu, Masahito;Moriwaki, Hisataka
通讯作者：
Moriwaki, Hisataka