Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women
Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women
复制标题
中国绝经后女性血清骨钙素水平与代谢综合征的关系
DOI：
10.1097/gme.0b013e318271b1da
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发表时间：
2012-12
影响因子：
2.7
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Luo, Yuqi;Gu, Chengchen;Bao, Yuqian;Jia, Weiping
目的研究骨钙素对能量代谢的调节作用。我们研究了中国绝经后妇女血清骨钙素水平与代谢综合征（MetS）的关系。方法选取中国上海4个社区41 ~ 78岁绝经后妇女1,789例。用电化学发光免疫分析法测定血清骨钙素水平。MetS的诊断定义遵循2007年《中国成人血脂异常防治指南》。结果met组血清骨钙素水平显著低于非MetS组（中位数[四分位数范围]，18.51 [15.52-23.46]vs 21.09 [16.98-26.26] ng/mL, P < 0.01）。随着血清骨钙素水平的增加，MetS及其组成部分的频率降低（趋势均P < 0.05），但高密度脂蛋白胆固醇水平较低的频率除外。血清骨钙素水平随代谢障碍数量的增加而显著降低（P < 0.01）。此外，二元logistic回归分析显示，血清骨钙素水平较高的参与者在met （OR, 0.123; 95% CI, 0.053-0.283）、中心性肥胖（OR, 0.134; 95% CI, 0.060-0.299）和高血糖（OR, 0.142; 95% CI, 0.066-0.302）方面的优势比（OR）较低。结论中国绝经后妇女血清骨钙素水平与MetS呈负相关，尤其是中心性肥胖和高血糖。
ObjectiveIt has been revealed that osteocalcin is a regulator of energy metabolism. We investigated the relationship between serum osteocalcin levels and metabolic syndrome (MetS) in Chinese postmenopausal women. MethodsA total of 1,789 postmenopausal women, aged 41 to 78 years, were selected from four communities in Shanghai, China. Serum levels of osteocalcin were measured with an electrochemiluminescence immunoassay. The diagnostic definition of MetS followed the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. ResultsSerum osteocalcin levels were significantly lower in participants with MetS than in non-MetS participants (median [interquartile range], 18.51 [15.52-23.46] vs 21.09 [16.98-26.26] ng/mL, P < 0.01). The frequency of MetS and its components decreased with increasing increments of serum osteocalcin levels (all P for trend < 0.05), with the exception of the frequency of low levels of high-density lipoprotein cholesterol. Serum osteocalcin levels significantly decreased with increasing number of metabolic disorders (P for trend < 0.01). Furthermore, binary logistic regression analysis revealed that participants with higher serum osteocalcin levels had lower odds ratios (ORs) for MetS (OR, 0.123; 95% CI, 0.053-0.283), central obesity (OR, 0.134; 95% CI, 0.060-0.299), and hyperglycemia (OR, 0.142; 95% CI, 0.066-0.302). ConclusionsSerum osteocalcin levels are negatively associated with MetS, particularly central obesity and hyperglycemia, in Chinese postmenopausal women.
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