Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis.
Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0202360
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
YektaKooshali MH
中科院分区：
文献类型：
--
作者：
JafariNezhad A;YektaKooshali MH
有许多流行病学证据表明，特发性肺纤维化（IPF）患者患肺癌的风险最高。我们对所有已发表的数据进行了系统综述，通过荟萃分析确定了IPF患者中发生的肺癌的特征。
本研究是根据PRISMA指南进行的。通过检索Web of Sciences、Scopus、PubMed/Medline、OVID和COCHRANE数据库收集文献，这些文献发表于2018年3月25日之前，与IPF患者的肺癌相关。使用标准关键词以及Mesh和Mesh Entry以及使用布尔运算符的所有可能的单词组合来搜索文章。数据搜索、提取和质量评估由两名研究人员独立完成。最后，使用了基于Cochrane检验的随机效应量和I²。该综述方案已在PROSPERO注册，注册号为：CRD42018094037。
基于对35项（0.18%）纳入研究进行的荟萃分析，IPF患者的总样本量估计为131947人，其中6384人患有肺癌。IPF患者中肺癌的总患病率估计为13.54%（95%置信区间：10.43 - 17.4），男性与女性相比、吸烟者与非吸烟者相比，患病率显著高出9倍。IPF中肺癌细胞（组织学）亚型的患病率从高到低依次为：鳞状细胞癌（SQCC，37.82%）、腺癌（ADC，30.79%）、小细胞癌（SmCC，20.48%）、大细胞癌（LCC，5.21%）和腺鳞癌（ADQC，4.81%）。IPF患者中肺癌的最高和最低分期分别估计为III期和II期。IPF患者中肺癌累及的最高部位是外周。此外，肿瘤累及区域的患病率从高到低依次估计为右下叶（RLL）、左下叶（LLL）、右上叶（RUL）和左上叶（LUL）区域。
IPF中的肺癌，最常见的是SQCC，多见于老年重度吸烟者，男性居多，位于外周区域和肺部下部占优势。
There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs’ patients. Articles were searched using standard keywords as well as Mesh and Mesh Entry and all probabilistic combinations of words using Boolean operators. Data searching, extracting and quality appraising were done by two researchers, independently. At last, Random-effects size based on Cochrane test and I2 were used. The review protocol has been registered in PROSPERO with ID: CRD42018094037. Based on the meta-analysis conducted in 35 (0.18%) included studies, the total sample size of patients with IPF was estimated 131947 among whom 6384 had LC. The total rate of LC prevalence in IPF patients was estimated to be 13.54% (95% CI: 10.43–17.4) that was significantly 9 times higher in men vs. Women and smoker vs. non-smoker. Highest to lowest prevalence of cellular (histological) subtypes of lung cancer in IPF were SQCC (37.82%), ADC (30.79%), SmCC (20.48%), LCC (5.21%), and ADQC (4.81%), respectively. The highest and lowest stage of lung cancer in IPF patients was estimated at III and II, respectively. The highest involvement location of lung cancer in IPF patients was in the Peripheral. Also, the prevalence of the tumor region involved from the highest to the lowest was estimated to be in the RLL, LLL, RUL and LUL regions. Lung cancer in IPF, most commonly SQCC, presents in elderly heavy smokers with a male, locating in peripheral regions and the lower part of lung predominance.
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作者：
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DOI：
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